Excitatory and inhibitory postsynaptic currents in a rat model of epileptogenic microgyria

Journal of Neurophysiology
K M Jacobs, D A Prince

Abstract

Developmental cortical malformations are common in patients with intractable epilepsy; however, mechanisms contributing to this epileptogenesis are currently poorly understood. We previously characterized hyperexcitability in a rat model that mimics the histopathology of human 4-layered microgyria. Here we examined inhibitory and excitatory postsynaptic currents in this model to identify functional alterations that might contribute to epileptogenesis associated with microgyria. We recorded isolated whole cell excitatory postsynaptic currents and GABA(A) receptor-mediated inhibitory currents (EPSCs and IPSCs) from layer V pyramidal neurons in the region previously shown to be epileptogenic (paramicrogyral area) and in homotopic control cortex. Epileptiform-like activity could be evoked in 60% of paramicrogyral (PMG) cells by local stimulation. The peak conductance of both spontaneous and evoked IPSCs was significantly larger in all PMG cells compared with controls. This difference in amplitude was not present after blockade of ionotropic glutamatergic currents or for miniature (m)IPSCs, suggesting that it was due to the excitatory afferent activity driving inhibitory neurons. This conclusion was supported by the finding that glu...Continue Reading

References

Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·O BernanderC Koch
Nov 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A PalminiR Ethier
Jun 1, 1990·The Japanese Journal of Psychiatry and Neurology·Y Tachibana
Jun 22, 1990·The Journal of Comparative Neurology·Y Chagnac-AmitaiD A Prince
Nov 1, 1989·Journal of Neurophysiology·Y Chagnac-Amitai, B W Connors
Jul 1, 1974·Journal of Neuropathology and Experimental Neurology·D P RichmanV S Caviness
Jan 1, 1995·Acta Neurologica Scandinavica. Supplementum·W A Hauser
Aug 1, 1993·Trends in Neurosciences·J BolzN Novak
May 1, 1994·Journal of Neurophysiology·S N HoffmanD A Prince
May 15, 1994·The Journal of Physiology·H B Michelson, R K Wong
Sep 1, 1993·The Journal of Comparative Neurology·G F Tseng, D A Prince
Apr 1, 1993·Journal of Neurophysiology·D A Prince, G F Tseng
May 1, 1996·Cerebral Cortex·K M JacobsD A Prince
Apr 1, 1996·Journal of Neurophysiology·P A Salin, D A Prince
Jul 15, 1996·Brain Research·G D RosenA M Galaburda
Aug 26, 1998·Neuropediatrics·A J BarkovichP Evrard
Jan 23, 1999·Journal of Neurophysiology·K M JacobsD A Prince
Jul 14, 1999·Epilepsia·N Chevassus-au-LouisY Ben-Ari
Oct 9, 1999·Epilepsy Research·K M JacobsD A Prince

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Citations

Nov 19, 2010·Cerebral Cortex·Fu-Wen Zhou, Steven N Roper
Sep 10, 2005·Epilepsy Currents·Jaideep Kapur, Stacey Trotter
Jun 12, 2009·Journal of Neurophysiology·Daniel L Jones, Scott C Baraban
May 9, 2008·Neuroreport·Steven W ThrelkeldRoslyn Holly Fitch
Dec 5, 2015·Frontiers in Pediatrics·Seok Kyu Kang, Shilpa D Kadam
Oct 3, 2008·Behavioral and Brain Functions : BBF·R Holly FitchJames J Chrobak
Apr 9, 2017·Journal of Computational Neuroscience·X Zhao, P A Robinson
Apr 8, 2015·Journal of Neuroscience Methods·Heiko J Luhmann
Jan 27, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carl E Stafstrom
Jul 26, 2014·Journal of Child Neurology·Tomoyuki Takano, Katsuyuki Matsui
Oct 24, 2007·The Journal of Comparative Neurology·Shilpa D Kadam, F Edward Dudek
Nov 26, 2009·Annals of Neurology·Joel S F GreenwoodScott C Baraban
Apr 28, 2006·Journal of Neurophysiology·Hui XiangSteven N Roper
May 4, 2007·Journal of Neurophysiology·A Zsombok, K M Jacobs
Apr 16, 2019·Frontiers in Neuroscience·Alfonso Represa
Nov 13, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·David HsuJohn M Beggs
Oct 13, 2006·Science's STKE : Signal Transduction Knowledge Environment·James O McNamaraA Soren Leonard
Dec 21, 2010·Brain Research·Amanda L George, Kimberle M Jacobs

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