Excitatory and inhibitory vestibular pathways to the extraocular motor nuclei in goldfish

Journal of Neurophysiology
W GrafR Baker

Abstract

Electrophysiological, ultrastructural, and immunohistochemical techniques were utilized to describe the excitatory and inhibitory vestibular innervation of extraocular motor nuclei in the goldfish. In antidromically activated oculomotor motoneurons, electrical stimulation of the intact contralateral vestibular nerve produced short-latency, variable amplitude electrotonic excitatory postsynaptic potentials (EPSPs) at 0.5-0.7 ms followed by chemical EPSPs at 1.0-1.3 ms. Stimulation of the ipsilateral vestibular nerve produced small amplitude membrane hyperpolarizations at a latency of 1.3-1.7 ms in which equilibrium potentials were slightly more negative than resting potentials. The inhibitory postsynaptic potentials (IPSPs) reversed with large amplitudes after the injection of chloride ions suggesting a proximal soma-dendritic location of terminals exhibiting high efficacy inhibitory synaptic conductances. In antidromically identified abducens motoneurons and putative internuclear neurons, electrical stimulation of the contralateral vestibular nerve produced large-amplitude, short-latency electrotonic EPSPs at 0.5 ms followed by chemical depolarizations at 1.2-1.3 ms. Stimulation of the ipsilateral vestibular nerve evoked IPSPs ...Continue Reading

References

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Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·A M PastorR Baker

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Citations

May 31, 2007·The Journal of Comparative Neurology·Kenichi Fujisawa, Masakazu Takahata
May 8, 2007·The Journal of Comparative Neurology·Brita RobertsonRéjean Dubuc
Dec 2, 2005·The Journal of Comparative Neurology·Hans StrakaEdwin Gilland
Mar 21, 2018·Journal of Neurology·Parthena SoupiadouHans Straka
Jun 30, 2018·Current Opinion in Neurobiology·Martha W Bagnall, David Schoppik

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