Excitatory effects of GABA on procerebrum neurons in a slug

Journal of Neurophysiology
S KobayashiE Ito

Abstract

Classical neurotransmitters, such as glutamate and γ-aminobutyric acid (GABA), often have different actions on invertebrate neurons from those reported for vertebrate neurons. In the terrestrial mollusk Limax, glutamate was found to function as an inhibitory transmitter in the procerebrum (PC), but it has not yet been clarified how GABA acts in the PC. We thus examined what effects GABA exerts on PC neurons in the present study. For this purpose, we first applied GABA to isolated PC preparations and recorded postsynaptic currents and potentials in PC neurons. The GABA application reduced the amplitude of inhibitory postsynaptic currents and depolarization-induced outward currents recorded in nonbursting neurons and increased the number of spontaneous spikes of nonbursting neurons. However, direct GABA-induced currents were not observed in either bursting or nonbursting neurons. These results suggest a potential direct effect of GABA on outward currents resulting in enhanced excitability of PC neurons. Next, we measured the change in [Ca(2+)](i) in cultured PC neurons by application of GABA. The GABA application increased spontaneous Ca(2+) events in cultured neurons. These Ca(2+) events were ascribable to the influx of extracel...Continue Reading

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Aug 28, 2010·The European Journal of Neuroscience·Suguru KobayashiRyota Matsuo

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Citations

Oct 22, 2014·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Yuko MatsuoRyota Matsuo
Dec 3, 2014·Current Opinion in Neurobiology·Leslie M Kay
May 18, 2016·The Journal of Comparative Neurology·Ryota MatsuoYuko Matsuo
Feb 14, 2014·The Journal of Comparative Neurology·Ryota MatsuoEtsuro Ito
Jan 31, 2020·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Ryota MatsuoYuko Matsuo

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