Excitatory innervation of caudal hypoglossal nucleus from nucleus reticularis gigantocellularis in the rat

Neuroscience
C C YangS H Chan

Abstract

We examined the possible innervation of the caudal hypoglossal nucleus by the nucleus reticularis gigantocellularis of the medulla oblongata, based on single-neuron recording and retrograde tracing experiments in Sprague-Dawley rats. Under pentobarbital sodium (50 mg/kg, i.p.) anesthesia, electrical stimulation of the caudal portion of the nucleus reticularis gigantocellularis with repetitive 0.5-ms rectangular pulses increased (46 of 51 neurons) the basal discharge frequency of spontaneously active cells, or evoked spike activity in silent, hypoglossal neurons located at the level of the obex. This excitatory effect was related to the intensity (25-100 microA) and/or frequency (0.5-20 Hz) of the stimulating pulses to the nucleus reticularis gigantocellularis. Perikaryal activation of neurons by microinjection of L-glutamate (0.5 nmol, 25 nl) into the caudal portion of the nucleus reticularis gigantocellularis similarly produced an excitatory action on eight of 14 hypoglossal neurons. Retrogradely labeled neurons were found bilaterally within the confines of the nucleus reticularis gigantocellularis following unilateral microinjection of wheatgerm agglutinin-conjugated horseradish peroxidase or Fast Blue into the corresponding ...Continue Reading

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Citations

Feb 28, 2009·Experimental Brain Research·Michelle Renee Ciucci, Nadine P Connor
Apr 5, 2005·Brain Research·Ines PoseFrancisco R Morales
Sep 1, 2000·Respiration Physiology·A J Berger
Jun 21, 2014·Medical Hypotheses·Jamaledin Abu GhaidaQasim Eldwairi
Oct 17, 2013·Toxicologic Pathology·Noel Downes, Pamela Mullins
Jun 13, 2003·Clinics in Chest Medicine·Sigrid Carlen Veasey
Aug 30, 2013·American Journal of Physiology. Cell Physiology·Xiao-Tao JinChun Jiang
Apr 4, 2000·Physiological Reviews·J C ReklingJ L Feldman

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