Excitatory input onto hilar somatostatin interneurons is increased in a chronic model of epilepsy.

Journal of Neurophysiology
Brian HalabiskyDavid A Prince

Abstract

The density of somatostatin (SOM)-containing GABAergic interneurons in the hilus of the dentate gyrus is significantly decreased in both human and experimental temporal lobe epilepsy. We used the pilocarpine model of status epilepticus and temporal lobe epilepsy in mice to study anatomical and electrophysiological properties of surviving somatostatin interneurons and determine whether compensatory functional changes occur that might offset loss of other inhibitory neurons. Using standard patch-clamp techniques and pipettes containing biocytin, whole cell recordings were obtained in hippocampal slices maintained in vitro. Hilar SOM cells containing enhanced green fluorescent protein (EGFP) were identified with fluorescent and infrared differential interference contrast video microscopy in epileptic and control GIN (EGFP-expressing Inhibitory Neurons) mice. Results showed that SOM cells from epileptic mice had 1) significant increases in somatic area and dendritic length; 2) changes in membrane properties, including a small but significant decrease in resting membrane potential, and increases in time constant and whole cell capacitance; 3) increased frequency of slowly rising spontaneous excitatory postsynaptic currents (sEPSCs) ...Continue Reading

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Citations

Aug 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tamar DugladzeTengis Gloveli
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert F HuntBret N Smith
Aug 30, 2014·Epilepsy Currents·Bret N Smith
Apr 8, 2014·Molecular Neurobiology·Elke ClynenJean-Michel Rigo
Jan 7, 2016·Cerebral Cortex·P M Sawant-PokamK C Brennan
Sep 11, 2012·Neuroscience·A BraginJ Engel
Jun 23, 2012·Epilepsy Research·Paul S Buckmaster, Megan M Haney
Mar 1, 2011·Neuroscience Letters·Huifang LiDavid Prince
Jun 12, 2013·The Journal of Comparative Neurology·Amy M SpiegelMichela Gallagher
May 27, 2016·Nature Reviews. Neuroscience·Joanna Urban-Ciecko, Alison L Barth
Jul 1, 2016·The Journal of Comparative Neurology·J J BotterillL E Kalynchuk
Oct 18, 2016·Frontiers in Neural Circuits·Iryna Yavorska, Michael Wehr
Nov 29, 2017·Frontiers in Neural Circuits·Lim-Anna SieuIvan Cohen
Nov 20, 2016·Epilepsy Currents·Bret N Smith
Jun 4, 2015·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Andrew J TrevelyanKevin J Staley
Oct 13, 2020·The Journal of Clinical Investigation·Punam A Sawant-PokamK C Brennan

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