Excitatory Microcircuits within Superficial Layers of the Medial Entorhinal Cortex

Cell Reports
Jochen WintererDietmar Schmitz

Abstract

The distinctive firing pattern of grid cells in the medial entorhinal cortex (MEC) supports its role in the representation of space. It is widely believed that the hexagonal firing field of grid cells emerges from neural dynamics that depend on the local microcircuitry. However, local networks within the MEC are still not sufficiently characterized. Here, applying up to eight simultaneous whole-cell recordings in acute brain slices, we demonstrate the existence of unitary excitatory connections between principal neurons in the superficial layers of the MEC. In particular, we find prevalent feed-forward excitation from pyramidal neurons in layer III and layer II onto stellate cells in layer II, which might contribute to the generation or the inheritance of grid cell patterns.

Citations

Feb 22, 2018·ELife·Simon Nikolaus Weber, Henning Sprekeler
Mar 8, 2018·Journal of Neurophysiology·Robert K NaumannAndrea Burgalossi
Oct 3, 2017·PLoS Computational Biology·Tiziano D'Albis, Richard Kempter
Sep 15, 2018·ELife·David C RowlandMay-Britt Moser
May 28, 2020·Frontiers in Systems Neuroscience·John J TukkerRobert N S Sachdev
Sep 14, 2018·Nature Communications·Ipshita ZutshiStefan Leutgeb
May 29, 2018·Cell and Tissue Research·Claudia BöhmDietmar Schmitz
Nov 5, 2019·Frontiers in Systems Neuroscience·Shinya OharaMenno P Witter
Oct 7, 2020·Hippocampus·Tiziano D'Albis, Richard Kempter
Aug 29, 2021·Nature Reviews. Neuroscience·Jon W RueckemannElizabeth A Buffalo
Aug 21, 2021·Annual Review of Cell and Developmental Biology·Maria Antonietta Tosches
Dec 8, 2021·PLoS Computational Biology·Michiel W H RemmeRichard Kempter

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