Excitatory Repetitive Transcranial Magnetic Stimulation Induces Contralesional Cortico-Cerebellar Pathways After Acute Ischemic Stroke: A Preliminary DTI Study

Frontiers in Behavioral Neuroscience
Jing LiWei-Hong Zhang

Abstract

Background: Repetitive transcranial magnetic stimulation (rTMS) is proved to be effective in facilitating stroke recovery. However, its therapeutic mechanism remains unclear. The present study aimed to investigate changes in white matter fractional anisotropy (FA) after excitatory rTMS to better understand its role in motor rehabilitation. Materials and Methods: Acute stroke patients with unilateral subcortical infarction in the middle cerebral artery territory were recruited. The patients were randomly divided into an rTMS treatment group and a sham group. The treatment group received a 10-day 5 HZ rTMS applied over the ipsilesional primary motor area beginning at about 4 days after stroke onset. The sham group received sham rTMS. Diffusion tensor imaging (DTI) data were collected in every patient before and after the rTMS or sham rTMS. Voxel-based analysis was used to study the difference in FA between the two groups. The trial of this article has been registered on the ClinicalTrials.gov and the identifier is NCT03163758. Results: Before the rTMS, there is no significant difference in FA between the two groups. Differently, after the treatment, the rTMS group showed increased FA in the contralesional corticospinal tract, the...Continue Reading

References

May 1, 1995·Archives of Physical Medicine and Rehabilitation·H S JørgensenT S Olsen
Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R XueS Mori
Jul 10, 2003·Lancet Neurology·Masahito Kobayashi, Alvaro Pascual-Leone
Jul 24, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·T AgoM Iida
Dec 3, 2003·Radiology·Setsu WakanaSusumu Mori
Mar 15, 2008·AJNR. American Journal of Neuroradiology·P MukherjeeR G Henry
Apr 3, 2009·NeuroRehabilitation·Sung Ho JangYoung Hyun Kwon
Jun 18, 2009·Neurorehabilitation and Neural Repair·Dennis A NowakGereon R Fink
Dec 18, 2010·Stroke; a Journal of Cerebral Circulation·Nora WeiduschatWolf Dieter Heiss
Mar 2, 2011·Neurorehabilitation and Neural Repair·Mingguo QiuAndrew J Butler
Aug 4, 2011·Clinics·Timothy V P Bliss, Sam F Cooke
Feb 2, 2013·AJNR. American Journal of Neuroradiology·A CancelliereW Yuan
Feb 27, 2013·Frontiers in Human Neuroscience·Zaixu CuiGaolang Gong
May 30, 2013·Stroke; a Journal of Cerebral Circulation·Cathy StinearWinston Byblow
Jan 15, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Emilie GeorgeJeffrey Greenfield
Jan 17, 2014·NeuroImage. Clinical·Yohei TakenobuHidenao Fukuyama
Dec 18, 2015·Circulation·UNKNOWN Writing Group MembersUNKNOWN Stroke Statistics Subcommittee
Apr 14, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Koichi HosomiYouichi Saitoh
May 15, 2016·Archives of Physical Medicine and Rehabilitation·Hongmei WenQing Mei Wang
Oct 25, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shingo MitakiShuhei Yamaguchi
Apr 21, 2017·Physical Therapy·James R CareyTeresa J Kimberley

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Citations

Nov 17, 2020·Frontiers in Neurology·Fan Su, Wendong Xu

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Methods Mentioned

BETA
SMA

Clinical Trials Mentioned

NCT03163758

Software Mentioned

Resting
- fMRI Data Analysis Toolkit
PANDA
xjView
AlphaSim

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