Excited-state intramolecular proton transfer of 2-acetylindan-1,3-dione studied by ultrafast absorption and fluorescence spectroscopy

Structural Dynamics
Pramod Kumar VermaTobias Brixner

Abstract

We employ transient absorption from the deep-UV to the visible region and fluorescence upconversion to investigate the photoinduced excited-state intramolecular proton-transfer dynamics in a biologically relevant drug molecule, 2-acetylindan-1,3-dione. The molecule is a ß-diketone which in the electronic ground state exists as exocyclic enol with an intramolecular H-bond. Upon electronic excitation at 300 nm, the first excited state of the exocyclic enol is initially populated, followed by ultrafast proton transfer (≈160 fs) to form the vibrationally hot endocyclic enol. Subsequently, solvent-induced vibrational relaxation takes place (≈10 ps) followed by decay (≈390 ps) to the corresponding ground state.

References

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Oct 10, 2014·Journal of the American Chemical Society·Pramod Kumar VermaTobias Brixner
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Feb 7, 2015·Physical Chemistry Chemical Physics : PCCP·Pramod Kumar VermaTobias Brixner
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Citations

Nov 2, 2018·Physical Chemistry Chemical Physics : PCCP·Alireza Marefat KhahChristof Hättig
Dec 14, 2016·Chemical Reviews·Tatu KumpulainenEric Vauthey
Jul 10, 2019·The Journal of Physical Chemistry. a·Xuemei HeJianping Wang

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