PMID: 9659981Jul 11, 1998Paper

Excitotoxic lesions of the hippocampus disrupt runway but not consummatory contrast

Behavioural Brain Research
C F FlahertyT Otto

Abstract

Rats shifted from a 12-pellet to a 1-pellet reward for running in a straight runway showed a decrease in start, run, and goal speed to levels below rats that received only the 1-pellet reward throughout training (a negative contrast effect). Contrast was greatest in the goal region of the runway. Rats with damage to the hippocampus produced by the excitotoxin ibotenic acid failed to show a negative contrast effect under these conditions. The same lesioned rats tested in a consummatory, contrast procedure following a shift from 32% to 4% sucrose showed a negative contrast effect equivalent to sham-lesioned rats. These data suggest that the hippocampus is necessary for behavioral outcomes based on encoding or comparison that affect approach behavior, but not for such outcomes that affect consummatory behavior.

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Citations

Jan 8, 2013·Appetite·Heather Francis, Richard Stevenson
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Ruey-Ming Liao, Feng-Jung Chuang
Nov 25, 2000·Behavioural Brain Research·M H Leszczuk, C F Flaherty
Feb 13, 2001·Behavioural Brain Research·K H ChanT L Davidson
Nov 24, 2001·Behavioural Brain Research·A L TracyT L Davidson
Jul 20, 2002·Neurotoxicology and Teratology·Juan A Salinas, Nicole C Huff
Apr 21, 2005·Behavioral Neuroscience·Norman Pecoraro, Mary F Dallman
Nov 17, 2011·PloS One·Rubén N MuzioMauricio R Papini
Jun 27, 2012·Behavioural Brain Research·Emma N MitchellEmma S J Robinson
Oct 24, 2013·Physiology & Behavior·Lidia ManzoCarmen Torres
Dec 23, 2014·Neuroscience Letters·Amanda C GlueckMauricio R Papini
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Mauricio R PapiniCarmen Torres
Oct 7, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S DavidsM Lotze
Mar 7, 2019·Frontiers in Psychology·José Manuel Lerma-CabreraFrancisca Carvajal

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