PMID: 9159502Apr 25, 1997Paper

Excitotoxic lesions of the pedunculopontine tegmental nucleus produce contralateral hemiparkinsonism in the monkey

Neuroscience Letters
J KojimaH Imai

Abstract

Dopaminergic nigrostriatal neurons, degeneration of which causes Parkinson's disease, are known to receive excitatory input almost exclusively from the pedunculopontine tegmental nucleus (PPN). We report here that excitotoxic lesions of the PPN produce abnormal motor signs relevant to hemiparkinsonism in the macaque monkey. Under the guidance of extracellular unit recordings, the electrophysiologically identified PPN was injected unilaterally with kainic acid. These PPN-lesioned monkeys exhibited mild to moderate levels of flexed posture and hypokinesia in the upper and lower limbs contralateral to the lesion. In most of the monkeys, such pathophysiological events were gradually improved and became stationary in 1-2 weeks. The hemiparkinsonian symptoms observed after PPN destruction might be ascribed to a decrease in nigrostriatal neuron activity due to excitatory input ablation.

References

Jul 1, 1990·Trends in Neurosciences·M R DeLong
Jan 1, 1991·Progress in Neurobiology·E Garcia-Rill
Oct 1, 1989·Trends in Neurosciences·R L AlbinJ B Penney
Mar 1, 1986·Brain Research·E Garcia-Rill
Jan 1, 1988·Experimental Brain Research·S T Sakai
Jun 25, 1984·Brain Research·E ScarnatiC Pacitti

❮ Previous
Next ❯

Citations

Apr 12, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Dipankar NandiJohn F Stein
Mar 19, 2008·Experimental Brain Research·Moran WeinbergerJonathan O Dostrovsky
Oct 14, 2005·Journal of Neurology·Masaru Matsumura
Jan 5, 2011·Journal of Neural Transmission·Clement HamaniAndres M Lozano
Apr 13, 2011·Journal of Neural Transmission·Ludvic ZrinzoJanice L Holton
Oct 29, 2000·Trends in Neurosciences·J A ObesoC W Olanow
Oct 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yoland SmithMahlon R DeLong
May 3, 2000·The European Journal of Neuroscience·M TakadaH Imai
Jul 16, 2010·The Journal of Clinical Investigation·Carine KarachiChantal François
Dec 12, 2001·Brain & Development·M Segawa
Feb 18, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Nadine K Gut, Philip Winn
Oct 23, 2015·Brain : a Journal of Neurology·Benjamin PasquereauRobert S Turner
Oct 10, 2009·Revue neurologique·M-U FerrayeP Pollak
Jan 27, 2009·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Bhooma R AravamuthanTipu Z Aziz
May 10, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Adriana Galvan, Thomas Wichmann
Sep 4, 2007·Brain Research Reviews·Kaoru Takakusaki
Dec 20, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Ned JenkinsonTipu Z Aziz
Jan 8, 2009·Annals of Neurology·Jose A ObesoC Warren Olanow
Aug 1, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Murielle U FerrayePierre Pollak
Nov 3, 2010·The European Journal of Neuroscience·Morten L KringelbachTipu Z Aziz
Sep 24, 2004·Neuroscience Research·K TakakusakiM Kashiwayanagi
Sep 27, 2005·Brain Research·Stewart D ClarkOlivier Civelli
Apr 2, 2002·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Dipankar NandiJohn F Stein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.