PMID: 2121545Oct 29, 1990Paper

Excitotoxin lesion of nucleus basalis causes a specific decrease in Go mRNA in cerebral cortex. Sensitivity to MK-801

FEBS Letters
H Wood, J de Belleroche

Abstract

Lesions of the ascending cholinergic pathway from nucleus basalis are known to have profound effects on cortical function. In particular, a substantial potentiation of carbachol-stimulated polyphosphoinositide turnover is detected from 1 day after lesion and is maintained for several days before returning to normal by 1 month. In this study the effect of this lesion was investigated on levels of three G-protein alpha-subunit mRNAs. Excitotoxin lesion of the nucleus basalis caused a selective reduction in the levels of Go alpha mRNA in cerebral cortex ipsilateral to the lesion, Gs alpha and Gi alpha mRNA being unaffected. The maximal effect was obtained at 3 days after lesion where levels of Go alpha mRNA were decreased by 40% compared to sham-operated animals. Levels of Go alpha mRNA returned to normal values by 28 days. Treatment with MK-801 caused a significant attenuation of the decrease in Go alpha mRNA, indicating the involvement of NMDA receptors in this response.

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·N SaitoE J Nestler
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·H ItohK Suzuki
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
May 1, 1983·Molecular and Cellular Biology·J L HallN J Cowan

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Citations

Jan 1, 1993·Journal of Neural Transmission. General Section·J F MarshallF B Weihmuller
Aug 1, 1993·Cephalalgia : an International Journal of Headache·R HeringJ de Belleroche

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