Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: in vivo binding studies

Endocrinology
J Funder, K Myles

Abstract

Adrenalectomized weanling rats injected with [3H]aldosterone plus excess RU486, with or without a range of doses of nonradioactive aldosterone or corticosterone, show tissue-specific patterns of competition for tracer binding to mineralocorticoid receptors (MR). From detailed dose-response curves, corticosterone in vivo shows approximately 3% the apparent affinity of aldosterone for MR in colon and kidney, approximately 30% for those in the heart, and approximately 300% in the hippocampus. We interpret these data as evidence that 1) relatively low levels of aldosterone cross the blood-brain barrier; and 2) specificity-conferring mechanisms in addition to the exclusion of corticosterone from epithelial MR are required for selective aldosterone action in sodium homeostasis.

Citations

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Mar 6, 2009·American Journal of Physiology. Renal Physiology·Joel C Geerling, Arthur D Loewy
May 12, 2004·Molecular and Cellular Endocrinology·John D BaxterPaul Webb
May 12, 2004·Molecular and Cellular Endocrinology·John W Funder
Apr 6, 2005·Trends in Endocrinology and Metabolism : TEM·GianPaolo RossiJohn W Funder
Apr 12, 2000·Kidney International·N Farman, B Bocchi
Dec 14, 2011·Molecular and Cellular Endocrinology·John W Funder
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Mar 17, 2010·Progress in Cardiovascular Diseases·John W Funder
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