Exclusion of DMRT1 as a candidate gene for canine SRY-negative XX sex reversal

The Veterinary Journal
K S D KothapalliV N Meyers-Wallen

Abstract

DMRT1, which encodes a zinc finger-like DNA binding motif, is a well-conserved gene that is involved in testis differentiation in a variety of mammalian and non-mammalian vertebrates. The objective of this study was to determine whether a DMRT1 microsatellite marker allele is associated with the affected phenotype in a pedigree of canine SRY-negative XX sex reversal generated from an American Cocker spaniel founder. Ten affected dogs and their parents and grandparents were genotyped. Four alleles at this locus and five different genotypes were found in this pedigree. All affected dogs inherited this trait from the foundation sire of this colony. Thus, the disease-causing mutation should be identical by descent in all affected dogs. Six affected dogs were found to have genotypes at this locus that were different from those of the founder sire. These results indicate that DMRT1 is an unlikely candidate gene for SRY-negative XX sex reversal in this model.

References

Sep 1, 1988·Human Genetics·V N Meyers-Wallen, D F Patterson
Jul 1, 1995·Molecular Reproduction and Development·V N Meyers-WallenB Hershfield
Apr 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Richard GuyonElaine A Ostrander
Sep 27, 2003·Science·Ewen F KirknessJ Craig Venter
Dec 20, 2003·Cytogenetic and Genome Research·A J PaskM B Renfree
Dec 20, 2003·Cytogenetic and Genome Research·S AoyamaM Nakamura

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Citations

Oct 19, 2011·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·V N Meyers-Wallen
Sep 17, 2009·Reproduction in Domestic Animals = Zuchthygiene·V N Meyers-Wallen
Aug 17, 2016·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Pietro ParmaEric Pailhoux
Jan 5, 2011·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·D A F VillagómezW A King
Mar 25, 2011·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·M SwitonskiN Mikolajewska

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