Exclusion of leukaemic meningitis by quantitation of T and B lymphocytes in cerebrospinal fluid

Australian and New Zealand Journal of Medicine
P B Harrison, A W Cripps

Abstract

Involvement of the central nervous system (CNS) in chronic lymphatic leukaemia (CLL) is rare. However, when a patient with CLL presented with meningeal symptoms and a high CSF lymphocyte count in the absence of identifiable infection, meningeal leukaemia was considered the most likely diagnosis. Subsequent quantitation of T and B lymphocytes in the blood and CSF was found to be a most valuable aid in excluding the diagnosis, and later a cryptococcal infection was proven. This case is reported to draw attention to the value of T and B lymphocyte quantitation where difficulty is experienced in interpretation of cells in CSF in patients with leukaemia or lymphoma.

References

Jun 2, 1978·JAMA : the Journal of the American Medical Association·S F DaviesM E Kaplan

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