PMID: 9004141Dec 1, 1996Paper

Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31

Journal of Medical Genetics
D AvramopoulosM B Petersen

Abstract

A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.

References

Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach
Apr 15, 1993·The New England Journal of Medicine·H A Quigley
May 1, 1993·Nature Genetics·V C SheffieldB E Nichols
Mar 1, 1964·The British Journal of Ophthalmology·A L CROMBIE, J F CULLEN
Jul 1, 1965·American Journal of Ophthalmology·D HARRIS
Jan 1, 1951·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·I BIRO
Feb 1, 1949·Archives of Ophthalmology·A POSNER, A SCHLOSSMAN

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Citations

Jul 4, 2001·European Journal of Human Genetics : EJHG·G KitsosK Psilas

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