Exclusion of VHa and VHy loci expression on individual B cells from normal and VH allotype-suppressed rabbits

European Journal of Immunology
K L KnightB Pernis


The distribution of two heavy chain subgroups, VHa and VHy, on rabbit peripheral blood lymphocytes was examined by double membrane immunofluorescence. Fluroescent anti-a1 and anti-y33 were found to react with separate B cell populations; no doubly stained cells were observed. Further evidence for the independent expression of genes controlling the VHa and VHy subgroups were obtained by neonatal suppression of a 2 or y33 in a2y33/a3y- heterozygous rabbits. Suppression of VHa did not affect the expression of VHy, nor did the suppression of VHy affect the expression of VHa. The expression of a single VH gene per B cell is in marked contrast to the simultaneous expression of multiple CH genes.


Jan 1, 1975·Contemporary Topics in Molecular Immunology·K L Knight, W C Hanly
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S M BergetP A Sharp
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J C CambierE S Vitetta
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Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·S TonegawaR Schuller
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Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C Brack, S Tonegawa
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Sep 28, 1973·Science·J E DarnellG R Molloy
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Jan 1, 1980·Immunogenetics·K L KnightR G Tissot
Oct 1, 1991·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D Meier, A S Kelus
Jul 10, 2004·Immunological Reviews·Maya Goldmit, Y Bergman

Related Concepts

Genome Mapping
Immunofluorescence Assay
Immunoglobulin Allotypes
Framework Region, Immunoglobulin
Immunoglobulin Heavy Chain Subgroup VH-III
Therapeutic Immunosuppression
Lymphoid Cells

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