Excretion mass balance evaluation, metabolite profile analysis and metabolite identification in plasma and excreta after oral administration of [14C]-meloxicam to the male cat: preliminary study

Journal of Veterinary Pharmacology and Therapeutics
P GrudéT Ebner

Abstract

The objective of this study was to investigate the metabolic pathways and routes of excretion of oral meloxicam in the cat. [(14)C]-meloxicam was administered orally to three fasted male cats. Urine, faeces, vomit and cage washes were collected over the following 144 h period. Blood was collected predosing and at 3 and 12 h postdosing. Metabolites were identified by HPLC/MS/MS. When possible a metabolic structure was proposed for each metabolite detected. Only unchanged meloxicam was identified in plasma. Five major metabolites were detected in urine and four in faeces, which were identified by HPLC/MS/MS as products of oxidative metabolism. No conjugated metabolites were detected. Elimination occurred early (61% during the first 48 h). A total of 21% of the recovered dose was eliminated in urine (2% as unchanged meloxicam, 19% as metabolites) and 79% in the faeces (49% as unchanged meloxicam, 30% as metabolites). The results indicate that after oral administration the major route of excretion of meloxicam in the cat is faecal and that the main pathway of biotransformation of meloxicam in the cat is oxidation.

References

Jan 1, 1989·Drug Metabolism Reviews·T F Woolf, L L Radulovic
Jan 1, 1973·Acta Pharmacologica Et Toxicologica·E Hietanen, H Vainio
Nov 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J SchmidH Wachsmuth
Apr 1, 1997·Alimentary Pharmacology & Therapeutics·M T Donnelly, C J Hawkey
Mar 11, 1998·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·C ChesnéT Sauter
Nov 30, 2004·American Journal of Veterinary Research·Pierre-Louis ToutainRüdiger Narbe
Aug 23, 2005·British Journal of Pharmacology·Jerome M GiraudelPierre-Louis Toutain
Apr 25, 2007·Veterinary Anaesthesia and Analgesia·B Duncan X LascellesSheilah A Robertson
Jun 19, 2010·Journal of Veterinary Pharmacology and Therapeutics·T LehrA Staab
Jul 22, 2010·Journal of Veterinary Pharmacology and Therapeutics·Z ZengH Ding

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Citations

Jun 16, 2011·Veterinary Anaesthesia and Analgesia·Gwendolyn L CarrollSandee M Hartsfield
Apr 22, 2021·Journal of Veterinary Pharmacology and Therapeutics·Jonathan N King, Martin Jung

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