Excretion of electrolytes in Brown Norway and Fischer 344 rats: effects of adrenalectomy and of mineralocorticoid and glucocorticoid receptor ligands

Experimental Physiology
Nathalie Marissal-Arvy, P Mormède

Abstract

Our previous studies showed that adrenalectomy (ADX) has surprisingly no effect on body weight and fluid intake in the Brown Norway rat strain, suggesting that mineralocorticoid receptor (MR)-mediated effects are present even in absence of corticosteroids in this strain. Moreover, glucocorticoid receptor (GR)-mediated mechanisms are more effective in Brown Norway than in Fischer 344 rats. Such functional differences in corticosteroid receptor pathways between Brown Norway and Fischer 344 rats led us to compare the effect of ADX and MR/GR-mediated actions on sodium and potassium excretion between these two rat strains. To this end, we first measured the effect of an acute high dose of aldosterone on the urinary Na+/K+ concentration ratio in intact and ADX Brown Norway and Fischer 344 rats. Second, to discriminate mineralocorticoid from glucocorticoid actions, we treated chronically ADX rats with increasing doses of aldosterone or RU28362, a pure GR agonist, in the drinking fluid. As sodium homeostasis involves salt appetite regulation, behaviour under mineralocorticoid control, we also measured saline preference in Brown Norway and Fischer 344 rats. Our data illustrate: (1) the very limited effect of ADX on body weight, food and...Continue Reading

References

Mar 11, 1977·Pflügers Archiv : European journal of physiology·H Sonnenberg
Mar 1, 1992·Hypertension·J D Horisberger, B C Rossier
Nov 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J W FunderL P Roy
Sep 1, 1989·Pflügers Archiv : European journal of physiology·T ShimizuM Imai
Jan 1, 1989·Life Sciences·L DevenportT Thomas
Jul 1, 1988·The Journal of Clinical Investigation·P M StewartC R Edwards
Oct 1, 1983·Pflügers Archiv : European journal of physiology·T J CampenD D Fanestil
Jan 1, 1984·The Journal of Endocrinology·C J KenyonD J Morris
Nov 30, 1994·Annals of the New York Academy of Sciences·M F DallmanK S Scribner
Dec 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·E R de KloetM S Oitzl
Jan 1, 1993·Annual Review of Physiology·J W Funder
May 2, 1998·The Japanese Journal of Physiology·Y Marunaka
Oct 27, 1998·Stress : the International Journal on the Biology of Stress·L Y MaR R Sakai
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·G H KimM A Knepper
Jun 9, 2000·Journal of Neuroendocrinology·N Marissal-ArvyP Mormède
Feb 24, 2001·American Journal of Physiology. Renal Physiology·N Farman, M E Rafestin-Oblin
Sep 22, 2001·Hypertension·P A Ortiz, J L Garvin
Feb 19, 2002·Advances in Physiology Education·Rachell E BoothJames D Stockand
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Olivier G MullerJean-Daniel Horisberger
May 12, 2004·Molecular and Cellular Endocrinology·Aditi BhargavaDavid Pearce
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·W C BoonJ G McDougall

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Citations

Jan 22, 2011·Acta Physiologica·A T UmbachF Lang
Apr 25, 2008·Journal of the American Society of Nephrology : JASN·Julie E GoodwinDavid S Geller
Jun 8, 2012·Domestic Animal Endocrinology·P Mormede, E Terenina
Mar 2, 2010·Biochemical and Biophysical Research Communications·Julie E GoodwinDavid S Geller
Jul 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Volker VallonFlorian Lang

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