Excretion of glutathione by methylglyoxal-resistant Escherichia coli

Journal of General Microbiology
K MurataI Chibata

Abstract

A methylglyoxal-resistant mutant of Escherichia coli B excreted glutathione into the growth medium, especially during growth on medium containing methylglyoxal. In the presence of methylglyoxal, the total amount of glutathione excreted was increased about 50-fold over that of the wild-type strain. The resistant mutant had high activities of two enzyme systems: a glutathione-forming enzyme system (consisting of gamma-glutamylcysteine synthetase and glutathione synthetase) and a glyoxalase system (consisting of glyoxalase I and glyoxalase II). Methylglyoxal resistance appeared to be due to the simultaneous increase in the activities of these two enzyme systems.

Citations

Oct 19, 2010·Applied and Environmental Microbiology·Evan D PepperSteven E Finkel
Oct 14, 2004·Applied Microbiology and Biotechnology·Yin LiJian Chen
Dec 1, 1982·Biotechnology and Bioengineering·T Yamané, S Shimizu
Oct 25, 2001·The Journal of Biological Chemistry·Brenda S KellyOwen W Griffith

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