PMID: 36259Jan 1, 1979

Excretion of kidney brush border antigens as a quantitative indicator of tubular damage

Current Problems in Clinical Biochemistry
J E Scherberich, W A Mondorf

Abstract

The excretion of antigens and enzymes derived from the brush border region was studied in patients with kidney diseases, after kidney transplantation, during administration of potential nephrotoxic drugs, before and after operations etc. The main portion of membrane constituents was excreted in the urine at an increased rate, compared to healthy persons, and was identical with glycoproteins artificially released from the brush border membrane surface. Antisera against brush border antigens, which had been isolated from urine by affinity chromatography, were used to localise the origin of urinary kidney tissue-proteins applying immunofluorescence microscopy.

Related Concepts

Immunofluorescence Assay
Urine
Microvilli
Enzymes, antithrombotic
Glycoproteins
Gamma-glutamyl transferase
Bright Disease
Immune Sera
Renal Tubule Structure
Immunofluorescence Microscopy

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