Excretion of lactose in urine as a measure of increased permeability of the lactating breast during inflammation

Acta Obstetricia Et Gynecologica Scandinavica
Catherine M FetherstonPeter E Hartmann

Abstract

The increased excretion of lactose in urine will be an accurate predictor of increased breast permeability during inflammation of the breast and therefore could predict whether there is a relationship between the severity and type of symptoms suffered during mastitis and changes in breast permeability. Twenty-six mothers were followed prospectively from Day 5 postpartum to the end of their lactation. Milk from each breast, blood, 24-hour urine samples, and data on breast and systemic pathologies were collected at reference intervals during the first three months postpartum, daily during the occurrence of any breast inflammation and 7 days after resolution of symptoms. The 24-h excretion of lactose in urine was higher during mastitis (p < 0.001), peaking at the commencement of the mastitis and decreasing over time until there was no significant difference at the time of follow-up when compared to mothers without mastitis (p < 0.25). The changes in lactose in urine were consistent with the changes in sodium, chloride, and lactose in milk, confirming milk expressed for sample analysis was representative of milk from the site of inflammation. Increased severity of breast symptoms experienced during mastitis was a significant predic...Continue Reading

Citations

Jul 31, 2007·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Catherine M FetherstonPeter E Hartmann
Jul 31, 2007·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Catherine M FetherstonPeter E Hartmann
Dec 18, 2008·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·C M FetherstonP E Hartmann
Dec 20, 2013·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Michiko YoshidaHideya Kodama
May 22, 2007·The Veterinary Journal·G A PapadopoulosG P J Janssens
Nov 17, 2009·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Linda J Kvist
Nov 8, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Won-Ho HahnNam Mi Kang
Mar 11, 2020·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Clarisa Medina PoelinizPaula Meier
Feb 9, 2012·Journal of Proteome Research·Claire E MolinariPeter E Hartmann

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