Excretion of pyridinium cross-links of collagen in ovariectomized rats as urinary markers for increased bone resorption

Calcified Tissue International
D BlackS P Robins

Abstract

Groups of 19-day-old rats were ovariectomized or were given sham operations. Measurements in urine of the pyridinium cross-links of collagen, pyridinoline and deoxypyridinoline, 7 weeks after surgery showed significantly higher amounts of cross-links relative to creatinine in the ovariectomized groups compared with the controls. Analyses before and after acid hydrolysis of the urine revealed that the increased excretion was only as free cross-link with no change in the concentrations of the bound forms. The loss of trabecular bone in the ovariectomized group was confirmed by immunocytochemical staining with antibodies to type I collagen. There were no differences between the ovariectomized and control groups in the concentrations of cross-links in the tibial bone or the articular cartilage. Measurements of free pyridinoline and deoxypyridinoline in urine therefore appear to provide a good index of the increased bone resorption induced by estrogen deficiency.

References

Jul 3, 1978·Biochimica Et Biophysica Acta·H SanadaT Takeda
Sep 14, 1978·Biochemical and Biophysical Research Communications·D FujimotoH Hayashi
May 16, 1987·Lancet·C ChristiansenP Rødbro
Apr 23, 1988·Lancet·I MacIntyreM J Healy
Oct 1, 1986·European Journal of Clinical Investigation·J C StevensonP A Hill
Mar 1, 1987·Calcified Tissue International·T J WronskiC C Walsh
Aug 21, 1987·Biochimica Et Biophysica Acta·S P Robins, A Duncan
Mar 1, 1986·Maturitas·S A DuursmaM C Slootweg
May 1, 1985·Calcified Tissue International·R L Jilka, J W Hamilton
May 1, 1985·Calcified Tissue International·T J WronskiL A Ignaszewski
Mar 13, 1971·British Medical Journal·B E Nordin
Feb 1, 1966·Analytical Biochemistry·H E Firschein, J P Shill
Dec 1, 1983·The American Journal of Medicine·B L Riggs, L J Melton
Dec 1, 1982·The Biochemical Journal·S P Robins
Dec 1, 1980·The Journal of Surgical Research·L MakowkaM J Phillips
Aug 31, 1982·Biochemical and Biophysical Research Communications·T OgawaY Kawanishi

❮ Previous
Next ❯

Citations

Aug 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C D EggerH Fleisch
Sep 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M J SeibelS P Robins
Dec 1, 1995·Calcified Tissue International·M RomanelloL Moro
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E CasariB Grazioli
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·H TamuraM Kitajima
Mar 10, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A LiptonR Knight
Oct 10, 2001·The British Journal of Nutrition·A Creedon, K D Cashman
Jan 20, 2012·Archives of Animal Nutrition·Li LuQingnan Li
Jun 1, 1993·European Journal of Clinical Investigation·A ColwellR Eastell
Oct 1, 1996·Journal of Medical Primatology·S CahoonA C Vailas
Jan 1, 1992·Annals of the Rheumatic Diseases·A D Woolf
Jun 25, 1999·Bioscience, Biotechnology, and Biochemistry·M KishiN Nishizawa
Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·X LiT Inoue
Sep 1, 1996·Journal of Endocrinological Investigation·K KawanaT Inoue
Jan 1, 1993·Connective Tissue Research·A J BaileyP W Thompson
Feb 19, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Markus J SeibelAndreas Grauer
Sep 1, 1992·Trends in Endocrinology and Metabolism : TEM·M J SeibelJ P Bilezikian
Oct 8, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·V SibiliaC Netti
May 4, 2005·Developmental Cell·Donald A GlassGerard Karsenty
Aug 3, 2006·International Journal of Radiation Biology·Peter NiehoffYahya Acil
Apr 1, 1996·Calcified Tissue International·N GaumetJ P Barlet
Sep 6, 1994·Annals of the New York Academy of Sciences·R A Greenwald
Mar 16, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C K SchlemmerM C Kruger
Jun 30, 1992·Biochemical and Biophysical Research Communications·A J BaileyP W Thompson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.