PMID: 589937Dec 1, 1977

Excretion of salt and water by patients with sickle-cell anaemia: effect of a diuretic and solute diuresis

Clinical Science and Molecular Medicine
T E Forrester, G A Alleyne


1. Patients with sickle-cell anaemia were unable to increase free water reabsorption (TcH2O) in response to intravenous hypertonic sodium chloride solution. 2. Ethacrynic acid caused a brisk natriuresis in patients with sickle-cell anaemia but fractional sodium excretion was lower in these patients. 3. These findings could be explained by abnormal function of the loop of Henle.


Feb 1, 1995·International Journal of Food Sciences and Nutrition·B P Kamalu
Dec 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M I ThabrewE A Bababunmi

Related Concepts

Anemia, Sickle Cell
Sodium Chloride, (24)NaCl

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