Excretion of urinary N-telopeptides reflects changes in bone turnover during ovarian suppression and indicates individually variable estradiol threshold for bone loss

Fertility and Sterility
W P DmowskiT H Clay

Abstract

To evaluate the effectiveness of N-telopeptides and E2 in monitoring bone turnover during GnRH agonist- (GnRH-a) or danazol-induced hypoestrogenism. Comparative, nonrandomized prospective study. Institute for the Study and Treatment of Endometriosis. Premenopausal women undergoing ovarian suppression with GnRH-a (n = 16) or danazol (n = 9). Serum and urine samples were collected and bone mineral density was measured before, during, and after treatment. N-telopeptide excretion, serum E2, and bone mineral density at L1 to L4 and femoral neck. During treatment in the GnRH-a group, mean E2 levels were 53% below and N-telopeptides were 38% above the mean baseline. At 1 month post-treatment, L1 to L4 bone mineral density decreased by 3.85%. In the danazol group, E2, N-telopeptides and L1 to L4 bone mineral density changed nonsignificantly in the opposite direction with the mean 1.25% increase in L1 to L4 at 1 month post-treatment. In combined groups, L1 to L4 bone mineral density better correlated with other measures than femoral neck bone mineral density. N-telopeptide excretion was more predictive of L1 to L4 change, with correlation the highest between N-telopeptides at month 4 and bone mineral density at month 1 afterward, while ...Continue Reading

Citations

Jan 1, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·H YilmazM Uner
Sep 3, 2014·Human Reproduction Update·Nicolas BourdelMichel Canis
Mar 3, 2001·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·K A Larmore, K O Klein

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