PMID: 7336976Sep 1, 1981Paper

Excretion of zinc in rat bile - a role of glutathione

Acta Pharmacologica Et Toxicologica
J AlexanderT Refsvik

Abstract

Fractionation of the bile from rats injected with 65ZnCl2 (5 mumol/kg) showed that zinc was mainly bound to low molecular weight compounds eluted corresponding to the zinc-glutathione complexes. Diethylmaleate (3.9 mmol/kg), cyclohexene oxide (4.9 mmol/kg) and acrylamide (3.5 mmol/kg) administered intraperitoneally to rats caused a rapid decrease in the endogenous excretion of both zinc and reduced glutathione into bile. This depression probably reflects the conjugation of the aforementioned substances to glutathione in the liver cells. These results indicate that zinc is transferred from liver to bile by glutathione dependent process and most likely as zinc-glutathione complexes.

References

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Citations

Jan 1, 1983·Acta Pharmacologica Et Toxicologica·T Refsvik
Aug 23, 1982·FEBS Letters·I AnundiM Vahter
Jan 1, 1991·Drug Metabolism Reviews·N Ballatori
Aug 1, 1994·Biological Trace Element Research·J W FinleyM Briske-Anderson
Jan 1, 1986·Acta Pharmacologica Et Toxicologica·J AlexanderA Mikalsen
May 31, 2007·Toxicology and Industrial Health·Nickolette RoneyChristopher T De Rosa
Aug 1, 1985·Biological Trace Element Research·C I Rosenblum, R M Leach
Jun 1, 1983·Biological Trace Element Research·S G Schäfer, W Forth
Mar 27, 2021·Metallomics : Integrated Biometal Science·Stephen A Pearson, J A Cowan
Nov 21, 1998·Journal of Chromatography. B, Biomedical Sciences and Applications·J Gailer, W Lindner
Jul 17, 1995·Biochimica Et Biophysica Acta·R P Oude ElferinkG M Groothuis
Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D HoltM Webb
Apr 1, 1984·Biochemical Pharmacology·N Ballatori, T W Clarkson

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