PMID: 3748782Aug 1, 1986Paper

Excretion-retention data of steady state gas exchange in tidal breathing. II. Dependency on the diffusion coefficient

Pflügers Archiv : European journal of physiology
A ZwartW R de Vries

Abstract

The steady state gas transfer properties of the lung can be derived from excretion-retention (E-R) data of inert tracer gases that are infused intravenously. E = PE/Pv and R = Pa/Pv, where PE, Pa and Pv represent the partial pressures of the tracer gases in mixed expired gas, arterial blood and mixed venous blood, respectively. In this paper, we investigate the influence of diffusive gas mixing in the lung on E and R. To that end, E-R data sets were simulated with a lung model that takes into account tidal breathing, the morphometric geometry of the airways, diffusion limited gas mixing in the alveolar space and gas dissolved in superficial lung tissue. The results show a linear relationship between R/E and D-0.5, where D represents the diffusion coefficient of the tracer gases in the alveolar gas mixture. This is in contrast to the results of simulations with a lung model that describes the different gas transport mechanisms, including diffusion, as a constant rate process, where a linear relationship between R/E and D-1 is predicted. It is further shown that E-R data of helium and sulphur hexafluoride cannot be used to demonstrate diffusion limited gas mixing in the lung, in particular, in the presence of a real shunt fractio...Continue Reading

References

Nov 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·W E TruogW A Hodson
Jul 1, 1976·Journal of Applied Physiology·M PaivaL P van der Linden
Mar 1, 1985·Journal of Applied Physiology·J R Torre-BuenoR E Moon
May 1, 1974·Journal of Applied Physiology·P D WagnerJ B West
Jun 1, 1981·Respiration Physiology·P ScheidJ Piiper
Mar 20, 1917·The Journal of Physiology·A Krogh, J Lindhard
Jun 1, 1949·Journal of Applied Physiology·R L RILEY, A COURNAND

❮ Previous
Next ❯

Citations

Oct 1, 1993·Pflügers Archiv : European journal of physiology·A C SchrikkerS C Luijendijk
Mar 1, 1989·Pflügers Archiv : European journal of physiology·A C SchrikkerS C Luijendijk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pflügers Archiv : European journal of physiology
A C SchrikkerS C M Luijendijk
Pflügers Archiv : European journal of physiology
A C SchrikkerS C M Luijendijk
Pflügers Archiv : European journal of physiology
A C SchrikkerS C M Luijendijk
© 2021 Meta ULC. All rights reserved