Executive control signals in orbitofrontal cortex during response inhibition

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Daniel W Bryden, Matthew R Roesch

Abstract

Orbitofrontal cortex (OFC) lesions produce deficits in response inhibition and imaging studies suggest that activity in OFC is stronger on trials that require suppression of behavior, yet few studies have examined neural correlates at the single-unit level in a behavioral task that probes response inhibition without varying other factors, such as anticipated outcomes. Here we recorded from single neurons in lateral OFC in a task that required animals in the minority of trials to STOP or inhibit an ongoing movement and respond in the opposite direction. We found that population and single-unit firing was modulated primarily by response direction and movement speed, and that very few OFC neurons exhibited a response independent inhibition signal. Remarkably, the strength of the directional signal was not diminished on STOP trials and was actually stronger on STOP trials during conflict adaptation. Finally, directional signals were stronger during sessions in which rats had the most difficulty inhibiting behavior. These results suggest that "inhibition" deficits observed with OFC interference studies reflect deficits unrelated to signaling the need to inhibit behavior, but instead support a role for OFC in executive functions rela...Continue Reading

Citations

Mar 5, 2016·Brain Imaging and Behavior·Eva MattRoland Beisteiner
Apr 14, 2016·Neuroscience·Jessica L Hurtubise, John G Howland
Jul 21, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel W BrydenMatthew R Roesch
May 21, 2016·Frontiers in Aging Neuroscience·David A S KaufmanWilliam M Perlstein
Jun 24, 2016·The European Journal of Neuroscience·Xiong XiaoZuoren Wang
Mar 22, 2018·Journal of Cognitive Neuroscience·Seng Bum Michael YooBenjamin Y Hayden
Nov 1, 2016·Neurorehabilitation and Neural Repair·Weihong YuanShari L Wade
Apr 24, 2019·Addiction Biology·Phillip StarskiDoo-Sup Choi
Dec 6, 2019·The European Journal of Neuroscience·Pragathi Priyadharsini BalasubramaniBenjamin Y Hayden
Mar 7, 2020·Proceedings of the National Academy of Sciences of the United States of America·Adam T BrockettMatthew R Roesch
Apr 13, 2018·Frontiers in Computational Neuroscience·Pragathi P BalasubramaniBenjamin Y Hayden
Dec 4, 2015·Journal of Neurophysiology·Caleb E StraitBenjamin Y Hayden
May 5, 2017·Frontiers in Neural Circuits·Matthew S D KerrJohn T Gale
Oct 12, 2019·F1000Research·Alik S WidgeBenjamin Y Hayden
May 5, 2021·Cognitive, Affective & Behavioral Neuroscience·Estée Rubien-ThomasB J Casey
Jul 27, 2021·Frontiers in Human Neuroscience·Niloufar ZebarjadiJonathan Levy
Jul 17, 2021·Human Brain Mapping·Emily Sophia NicholsAdrian Mark Owen

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