Executive (dys)function after stroke: special considerations for behavioral pharmacology

Behavioural Pharmacology
Jessica M PovroznikElizabeth B Engler-Chiurazzi

Abstract

Stroke is a worldwide leading cause of death and long-term disability with concurrent secondary consequences that are largely comprised of mood dysfunction, as well as sensory, motor, and cognitive deficits. This review focuses on the cognitive deficits associated with stroke specific to executive dysfunction (including decision making, working memory, and cognitive flexibility) in humans, nonhuman primates, and additional animal models. Further, we review some of the cellular and molecular underpinnings of the individual components of executive dysfunction and their neuroanatomical substrates after stroke, with an emphasis on the changes that occur during biogenic monoamine neurotransmission. We concentrate primarily on changes in the catecholaminergic (dopaminergic and noradrenergic) and serotonergic systems at the levels of neurotransmitter synthesis, distribution, reuptake, and degradation. We also discuss potential secondary stroke-related behavioral deficits (specifically, poststroke depression as well as drug-abuse potential and addiction) and their relationship with stroke-induced deficits in executive function, an especially important consideration given that the average age of the human stroke population is decreasing...Continue Reading

References

Mar 1, 1979·Stroke; a Journal of Cerebral Circulation·T KandaY Takagi
Mar 11, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KawaiI Klatzo
Apr 1, 1989·Molecular and Chemical Neuropathology·H Z TangY Q Huang
Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jan 1, 1988·Journal of Neural Transmission·J Weinberger, J Nieves-Rosa
Mar 1, 1988·British Journal of Clinical Pharmacology·R A PrentisS R Walker
Apr 1, 1987·Journal of Neurosurgery·E J SinarG M Teasdale
May 1, 1985·Annals of Neurology·B D WatsonM D Ginsberg
Jan 1, 1966·Acta Psychologica·A R Jensen, W D Rohwer
Jan 1, 1984·Stroke; a Journal of Cerebral Circulation·L M Binder
Jan 1, 1980·Critical Reviews in Clinical Laboratory Sciences·R A Rush, L B Geffen
Dec 1, 1995·Stroke; a Journal of Cerebral Circulation·D Walker-BatsonR Greenlee
Mar 24, 2000·Cerebral Cortex·A BecharaA R Damasio
Mar 24, 2000·Cerebral Cortex·E D LondonA Weinstein
Aug 10, 2000·Experimental Brain Research·R Levy, P S Goldman-Rakic
Feb 19, 2002·The European Journal of Neuroscience·Marko HuotariPekka T Männistö
May 3, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T PohjasvaaraT Erkinjuntti
Jul 20, 2002·Progress in Neurobiology·André Nieoullon
Mar 26, 2003·ILAR Journal·Richard J Traystman
Oct 16, 2003·Dementia and Geriatric Cognitive Disorders·Matthias W RiepeRoman Huber
Dec 23, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David VirleyA Jackie Hunter
Jan 30, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Helen M Bramlett, W Dalton Dietrich
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier Mestas, Christopher C W Hughes
Sep 15, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hideo TsukadaTakeharu Kakiuchi
Feb 25, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoshinori OkadaJoh-E Ikeda
May 14, 2005·Free Radical Biology & Medicine·Peter J Crack, Juliet M Taylor
Jun 14, 2005·Biological Psychiatry·Amy F T Arnsten, Bao-Ming Li
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Mohammad S AlavijehAlan M Palmer
Feb 3, 2007·Archives of Physical Medicine and Rehabilitation·Sandra ZinnH Scott Swartzwelder
Feb 6, 2007·Journal of Neurology·Simone ZittelJoachim Liepert
Apr 7, 2007·Current Opinion in Psychiatry·Samuel R Chamberlain, Barbara J Sahakian
Aug 19, 2007·Journal of Experimental Psychology. General·Pablo GomezManuel Perea
Sep 6, 2007·Neuropsychology Review·María Beatriz Jurado, Mónica Rosselli
Sep 14, 2007·The Clinical Neuropsychologist·Chwen-Yng SuNai-Wen Guo
Sep 18, 2007·The European Journal of Neuroscience·Victoria WindleDale Corbett

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Citations

Dec 18, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rafael Pazinatto de AguiarRúbia Maria Weffort de Oliveira
Mar 9, 2021·Topics in Stroke Rehabilitation·Candice OsborneShannon Juengst

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Methods Mentioned

BETA
transgenic
deamination
genotyping

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