Executive dysfunction assessed by Clock-Drawing Test in older non-demented subjects with metabolic syndrome is not mediated by white matter lesions

Psychiatry and Clinical Neurosciences
Giovanni ViscogliosiEvaristo Ettorre

Abstract

Metabolic syndrome (MetS) has been associated with greater occurrence of white matter hyperintensities (WMH). It remains uncertain whether MetS as a construct is associated with poorer cognitive performances. This study explores whether MetS is associated with poorer performances in global and domain-specific cognitive tests in older non-demented subjects independently of its individual components, WMH severity and other variables. MetS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III definition. Brain magnetic resonance studies (1.5T) were performed. Deep and periventricular WMH were graded using the Fazekas scale. Subjects underwent the Mini-Mental State Examination, the Babcock Short Story Recall test and the Clock-Drawing Test (CDT). Eighty community-dwellers aged 67-91 years were studied. Subjects with MetS (n = 35) had more severe WMH, and poorer performances on the CDT (P = 0.003) and the Babcock Short Story Recall test (P = 0.027). After multiple adjustment, MetS was inversely associated with CDT scores (B = -1.285; 95% confidence interval = -1.996--0.575; P = 0.001) but not with episodic memory. Results were not affected by WMH severity. Interestingly, none of the individu...Continue Reading

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Citations

Jan 25, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Giovanni ViscogliosiEvaristo Ettorre
Mar 24, 2016·Journal of the American Geriatrics Society·Giovanni ViscogliosiEvaristo Ettorre
Oct 30, 2018·International Journal of Geriatric Psychiatry·Thitiporn SupasitthumrongKenneth Shulman
Sep 29, 2019·Journal of Alzheimer's Disease : JAD·Sini ToppalaJuha O Rinne
May 31, 2017·International Journal of Geriatric Psychiatry·Elias HazanKenneth Shulman
Dec 24, 2019·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Nina Coll-PadrósLorena Rami
Jul 30, 2019·American Journal of Alzheimer's Disease and Other Dementias·Xue WangQian Gao

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