Executive Dysfunction Detected with the Frontal Assessment Battery in Alzheimer's Disease Versus Vascular Dementia

Journal of Alzheimer's Disease : JAD
Grazia D'OnofrioDavide Seripa

Abstract

Alzheimer's disease (AD) and vascular dementia (VaD) lead to progressive decline in executive function. We estimated the prevalence of executive dysfunction in AD and VaD patients, investigating cognitive, functional, and clinical correlates and also using a multidimensional approach based on a standardized comprehensive geriatric assessment (CGA). We included 215 patients (115 AD patients and 100 VaD patients) consecutively evaluated with a complete cognitive and affective assessment, a CGA, and the Frontal Assessment Battery (FAB) with six subtests investigating conceptualization, mental flexibility, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy. The prevalence of dysexecutive syndrome screened with a FAB score <12 points was high in both AD (97 patients) and VaD (77 patients) (84.3% versus 77.0%, p = 0.171). AD patients were significantly younger, with higher grade of cognitive impairment and less severe comorbidity and polypharmacy than VaD patients. AD patients showed a significantly higher impairment in FAB total score and five FAB subtests (conceptualization, motor programming, sensitivity to interference, inhibitory control, and environmental autonomy) than VaD patients. ...Continue Reading

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Citations

Sep 22, 2020·Journal of Clinical and Experimental Neuropsychology·Yana SuchyMadison A Niermeyer
Mar 21, 2020·International Journal of Molecular Sciences·Jose A SantiagoJudith A Potashkin
Feb 9, 2021·Journal of Alzheimer's Disease : JAD·Xudong LiJinsong Jiao
Jun 8, 2021·Journal of Alzheimer's Disease : JAD·Fabrizio VecchioPaolo Maria Rossini

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