PMID: 16519265Mar 8, 2006Paper

Executive function asymmetry in older adults genetically at-risk for Alzheimer's disease: verbal versus design fluency

Journal of the International Neuropsychological Society : JINS
Wes S HoustonMark W Bondi

Abstract

Recent studies have reported cognitive asymmetries in patients with Alzheimer's disease (AD) and in individuals with apolipoprotein E epsilon4 (APOE epsilon4) genotype who are in the preclinical phase of AD. This increased frequpncy of cognitive asymmetry, typically defined as a significant discrepancy (in either direction) between verbal and spatial abilities, often occurs despite an absence of differences on traditional measures of central tendency (i.e., mean test scores). We prospectively studied the relationship between APOE genotype and two modality-specific executive-function tasks: The Verbal Fluency and Design Fluency tests of the Delis-Kaplan Executive Function System (D-KEFS) in 52 normal functioning older adult participants who were grouped according to the presence (n=24) or absence (n=28) of the APOE e4 allele. Nondemented older adults with the APOE epsilon4 allele demonstrated a greater frequency of cognitive asymmetric profile on the new switching conditions of the Verbal and Design Fluency measures than the APOE non-epsilon4 individuals. This study further supports the utility of assessing cognitive asymmetry for the detection of subtle cognitive differences in individuals at-risk for AD, and suggests that dual...Continue Reading

References

Jul 1, 1992·Journal of Clinical and Experimental Neuropsychology·D C DelisJ V Filoteo
Jun 1, 1990·Archives of Neurology·D GalaskoL J Thal
Jun 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J V HaxbyS I Rapoport
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Mar 12, 1997·JAMA : the Journal of the American Medical Association·D A EvansR Mayeux
Apr 16, 1998·Alzheimer Disease and Associated Disorders·R W WarzokL C Walker
Oct 15, 1998·Alzheimer Disease and Associated Disorders·M C MorrisD A Evans
Nov 7, 1999·Journal of Clinical and Experimental Neuropsychology·N J FisherL A Bieliauskas
Aug 17, 2000·The New England Journal of Medicine·S Y BookheimerG W Small
Nov 4, 2000·Neurochemical Research·E Giacobini
Apr 20, 2001·Journal of Clinical and Experimental Neuropsychology·T DemaduraD Salmon
Jul 19, 2001·Journal of the International Neuropsychological Society : JINS·M S AlbertK Jones
Oct 31, 2002·Journal of the International Neuropsychological Society : JINS·Kelly L LangeLeon J Thal
Aug 7, 2003·Journal of the International Neuropsychological Society : JINS·Michael J FintonNeill R Graff-Radford

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Citations

Dec 14, 2011·Langenbeck's Archives of Surgery·Dominika BabińskaZbigniew Sledziński
May 4, 2007·Neuropsychology Review·Christina E Wierenga, Mark W Bondi
Mar 19, 2008·Neuropsychology Review·Mark W BondiDavid P Salmon
Dec 21, 2007·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Leigh J BeglingerDavid Kareken
Sep 12, 2006·Journal of the International Neuropsychological Society : JINS·Elizabeth W TwamleyMark W Bondi
Dec 3, 2010·Journal of the International Neuropsychological Society : JINS·Carrie-Ann H StrongJacobus Donders
Jan 29, 2013·Comprehensive Psychiatry·Tone HellvinIngrid Melle
Jan 14, 2016·Journal of Clinical and Experimental Neuropsychology·W Alexander AlversonRachelle S Doody
Feb 8, 2011·Comprehensive Psychiatry·Elizabeth A BarrettIngrid Melle
Jul 25, 2015·European Eating Disorders Review : the Journal of the Eating Disorders Association·Eyal HeledRichard P Ebstein
May 23, 2014·Frontiers in Psychiatry·Anja VaskinnKjetil Sundet
Oct 8, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Nils Eiel SteenOle A Andreassen
Jan 1, 2009·American Journal of Alzheimer's Disease and Other Dementias·Ludovico MinatiGiorgio Giaccone
May 15, 2008·The Journal of Nervous and Mental Disease·Paul H LysakerGiuseppe Nicolò
Nov 12, 2019·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Ashita S GurnaniBrandon E Gavett
Jun 27, 2019·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Paulina V DevoraJared F Benge
Jun 22, 2021·Journal of Alzheimer's Disease : JAD·Yu-Ling ChangDi-Hua Luo
Aug 9, 2021·Psychiatry Research. Neuroimaging·Bárbara Duarte-AbrittaSalvador M Guinjoan

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