Exenatide Delays the Progression of Nonalcoholic Fatty Liver Disease in C57BL/6 Mice, Which May Involve Inhibition of the NLRP3 Inflammasome through the Mitophagy Pathway

Gastroenterology Research and Practice
Ning ShaoHong-Yu Kuang

Abstract

This study is aimed at investigating whether exenatide (Exe) delays the progression of nonalcoholic fatty liver disease (NAFLD) in C57BL/6 mice by targeting the NLRP3 inflammasome through the autophagy/mitophagy pathway. Thirty male C57BL/6 mice were randomly divided into three groups: control group (n = 10), model group (n = 10), and Exe (exenatide) group (n = 10). Mouse models of NAFLD and diabetes were established using a high-fat diet and streptozocin. The levels of fasting blood glucose (FBG), total cholesterol (TC), and triglyceride (TG) in the serum were significantly reduced after Exe treatment. The body weight, liver weight/body weight, and number of lipid droplets in the liver significantly decreased in Exe-treated mice. Treatment with Exe markedly reduced the levels of liver lipids, malondialdehyde (MDA), and alanine aminotransferase (ALT) in serum and livers. The number of autophagosomes increased significantly in the Exe group. The expression of LC3A/B-II/I, Beclin-1, Parkin, and BNIP3L increased significantly, whereas NLRP3 and IL-1β proteins were suppressed after Exe treatment. We successfully established a mouse model of NAFLD and diabetes. Exe may reduce oxidative stress injury and inhibit the NLRP3 inflammasom...Continue Reading

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Citations

Oct 15, 2019·Acta Biochimica Et Biophysica Sinica·Zhenrui CaoGuiqiong He
Oct 28, 2019·Frontiers in Pharmacology·Zuqing SuGuangjuan Zheng
Sep 18, 2020·International Journal of Molecular Sciences·Jin Hyun KimSoo Kyoung Kim
Feb 11, 2020·Frontiers in Cardiovascular Medicine·Amandine ThomasRoberta A Gottlieb
Sep 22, 2020·World Journal of Hepatology·Areti SofogianniEvangelos Cholongitas
Oct 13, 2020·Journal of Cellular Physiology·Jiafeng LiKailiang Zhou
Feb 16, 2021·World Journal of Hepatology·Elias KouroumalisDimitrios N Samonakis
Apr 3, 2021·Autophagy·Yasmina Filali-MouncefFulvio Reggiori
Jun 19, 2021·Frontiers in Cell and Developmental Biology·Ana Isabel Álvarez-MercadoAraní Casillas-Ramírez
May 30, 2021·Journal of Gastroenterology and Hepatology·Itzayana Rodríguez-AntonioNatalia Nuño-Lámbarri

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Methods Mentioned

BETA
MDA

Software Mentioned

SPSS
Image Lab
Exe

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