Exenatide inhibits necrosis by enhancing angiogenesis and ameliorating ischemia/reperfusion injury in a random skin flap rat model.

International Immunopharmacology
Ji-Bing HeDing-Sheng Lin

Abstract

Random skin flaps are often used for plastic repair because they are convenient and flexible. However, necrosis of flaps is a common complication that may lead to disastrous consequences. Exenatide, a glucagon-like peptide 1 receptor agonist, can enhance angiogenesis and ameliorate ischemia/reperfusion injury. Our experiments explored random skin flap outcomes after its use. We established modified dorsal McFarlane flaps on 54 Sprague-Dawley rats and divided the rats into three groups (control, Exe-I, and Exe-II). We intraperitoneally injected either 4 or 8 μg/kg/day exenatide into the rats of the Exe-I and Exe-II groups, respectively. On the seventh day after the operation, we measured the levels of superoxide dismutase (SOD) and malondialdehyde (MDA). Tissue sections were obtained for histopathological and immunohistochemical analyses, and we evaluated the expression of vascular endothelial growth factor (VEGF), interleukin (IL) 6, IL-1β, nuclear factor kappa beta (NF-κB), Toll-like receptor 4 (TLR4), and tumor necrosis factor α (TNF-α). We measured blood flow reconstruction and angiogenesis using laser Doppler blood flowmetry and lead oxide/gelatin angiography, respectively. Exenatide increased the average survival area of t...Continue Reading

References

Feb 15, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G Tsoulfas, D A Geller
Sep 9, 2004·American Journal of Physiology. Endocrinology and Metabolism·Thomas NyströmAke Sjöholm
Jan 1, 1997·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·J M DavidsonD Quaglino
Mar 24, 2012·Current Medical Research and Opinion·Edoardo Mannucci, Ilaria Dicembrini
Apr 2, 2013·Biochemical and Biophysical Research Communications·Hye-Min KangChan Park
Nov 28, 2013·Molecular and Cellular Endocrinology·Sarah Noerklit RoedMaria Waldhoer
Aug 20, 2014·The Journal of Surgical Research·Shayandokht TalebAhmad Reza Dehpour
Aug 26, 2014·Therapeutic Advances in Endocrinology and Metabolism·Marwa R Al-Badri, Sami T Azar
Oct 14, 2014·Frontiers in Immunology·Takumi Kawasaki, Taro Kawai
Jul 15, 2015·European Journal of Pharmacology·Stefano BacciLaura Raimondi
Apr 26, 2016·Mediators of Inflammation·Young-Sun Lee, Hee-Sook Jun
Dec 21, 2016·The Journal of Surgical Research·Jun-Neng RoanChen-Fuh Lam
Jan 27, 2019·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chengliang DengDali Wang
Feb 21, 2019·Acta Cirúrgica Brasileira·Xiaodong WangDongfang Bai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Reviews. Drug Discovery
Mayer B DavidsonPeter Kirkpatrick
Diabetic Medicine : a Journal of the British Diabetic Association
J C Ferrer-GarciaC Sánchez-Juan
© 2021 Meta ULC. All rights reserved