Exendin-4, a glucagon-like peptide-1 analogue accelerates healing of chronic gastric ulcer in diabetic rats

PloS One
Yen-Cheng ChenChen-Fuh Lam

Abstract

Diabetes mellitus is an independent risk factor for impaired healing of peptic ulcers, and there are currently no supplementary therapeutics other than the standard antipeptic medicine to improve the ulcer healing in diabetes. This study examined the potential pleiotropic effect of a glucagon-like peptide (Glp)-1 analogue exendin (Ex)-4 on the regeneration of gastric ulcer in streptozotocin-induced diabetic rats. Chronic ulcer was created in rat stomach by submucosal injection of acetic acid and peri-ulcer tissues were analyzed 7 days after operation. Ulcer wound healing was impaired in diabetic rats with suppressed tissue expression of eNOS and enhanced levels of pro-inflammatory reactions. Treatment with intraperitoneal injection of Ex4 (0.5 μg/kg/d) significantly reduced the area of gastric ulcer without changing blood glucose level. Ex-4 restored the expression of pro-angiogenic factors, and attenuated the generation of regional inflammation and superoxide anions. The improvement of ulcer healing was associated with increased expression of MMP-2 and formation of granulation tissue in the peri-ulcer area. Administration of Ex4 may induce pro-angiogenic, anti-inflammatory and anti-oxidative reactions in the peri-ulcer tissue ...Continue Reading

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Citations

Oct 18, 2019·Current Drug Delivery·Di ZhangYueze Liu
Sep 27, 2018·Current Protein & Peptide Science·Jean-Étienne R L Morlighem, Gandhi Radis-Baptista
Feb 20, 2020·Current Pharmaceutical Biotechnology·Hadi RajabiDavoud Sanajou
Jul 9, 2021·British Journal of Pharmacology·Jens Juul HolstKaare Villum Grunddal

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Methods Mentioned

BETA
dissection
ELISA
biopsies

Software Mentioned

SigmaStat Scientific
ImageJ

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