Exendin-4 attenuates brain death-induced liver damage in the rat

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Rodrigo CarlessiDaisy Crispim

Abstract

The majority of liver grafts destined for transplantation originate from brain dead donors. However, significantly better posttransplantation outcomes are achieved when organs from living donors are used, suggesting that brain death (BD) causes irreversible damage to the liver tissue. Recently, glucagon-like peptide-1 (GLP1) analogues were shown to possess interesting hepatic protection effects in different liver disease models. We hypothesized that donor treatment with the GLP1 analogue exendin-4 (Ex-4) could alleviate BD-induced liver damage. A rat model of BD was employed in order to estimate BD-induced liver damage and Ex-4's potential protective effects. Liver damage was assessed by biochemical determination of circulating hepatic markers. Apoptosis in the hepatic tissue was assessed by immunoblot and immunohistochemistry using an antibody that only recognizes the active form of caspase-3. Gene expression changes in inflammation and stress response genes were monitored by quantitative real-time polymerase chain reaction. Here, we show that Ex-4 administration to the brain dead liver donors significantly reduces levels of circulating aspartate aminotransferase and lactate dehydrogenase. This was accompanied by a remarkable ...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·H H Draper, M Hadley
Jan 1, 1984·Methods in Enzymology·H Aebi
Aug 10, 1995·The New England Journal of Medicine·P I TerasakiS Takemoto
Mar 4, 2000·The New England Journal of Medicine·S HariharanD Stablein
Jun 24, 2000·The New England Journal of Medicine·C Parikh, D H Ellison
Mar 27, 2001·Transplantation Proceedings·J PratschkeN L Tilney
Jun 28, 2003·Transplantation·Vassilios S AvlonitisJohn H Dark
Oct 28, 2003·Transplantation·Joost A B Van Der HoevenRutger J Ploeg
Feb 9, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Peter OlingaGeny M M Groothuis
Aug 3, 2005·BioTechniques·Marisa L Wong, Juan F Medrano
Dec 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaokun DingFrank A Anania
Apr 14, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S WeissJ Pratschke
Mar 13, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nitika Arora GuptaFrank A Anania
Dec 29, 2010·Journal of Proteome Research·Charlotte Welinder, Lars Ekblad
Jun 15, 2011·Cell Transplantation·S R CechinR L Pastori
Jun 30, 2011·AIDS Patient Care and STDs·Lisa B Hightow-WeidmanUNKNOWN YMSM of Color SPNS Initiative Study Group
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Gianluca Svegliati-BaroniAmalia Gastaldelli
Mar 24, 2012·The Journal of Surgical Research·Juan Sebastian DanobeitiaLuis A Fernandez
Feb 26, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Lili ZhangGangyi Yang
Oct 4, 2013·Journal of Translational Medicine·Philipp StieglerVanessa Stadlbauer
Oct 22, 2013·Transplantation·Tatiana H RechCristiane B Leitão
May 16, 2015·Molecular and Cellular Endocrinology·Rodrigo CarlessiDaisy Crispim

❮ Previous
Next ❯

Citations

Feb 14, 2019·Molecular Biology Reports·Natália Emerim LemosDaisy Crispim
Dec 12, 2018·Frontiers in Endocrinology·Jordan RowlandsRodrigo Carlessi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiovascular Biology of GLP-1

Glucagon-like peptide 1 (GLP-1) plays a role in glucose metabolism, energy homeostasis, and inflammation suppression. GLP-1 receptor signaling has been shown to impact cardiovascular function. This feed focuses on the role of GLP-1 and GLP-1 receptor agonists on cardiovascular biology.

Related Papers

BioMed Research International
Rolando A RebolledoHenri G D Leuvenink
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Vassilios S AvlonitisJohn H Dark
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Xiaochen WangJiayu Xu
© 2021 Meta ULC. All rights reserved