Exercise and gall bladder function

Sports Medicine
A C Utter, F L Goss

Abstract

Epidemiological research has demonstrated protective effects of varying strength from physical activity against the risk for several chronic diseases such as coronary heart disease, hypertension, non-insulin-dependent diabetes mellitus and osteoporosis. Epidemiological studies have been supported by experimental research showing that exercise training improves coronary heart disease risk factors and other health-related factors. In contrast, the association between physical activity, exercise and gall stone disease has not yet been firmly established. This paper presents the theoretical role of aerobic exercise: (i) in the primary prevention of gall stone disease; and (ii) as a potential prokinetic agent in high risk gall stone disease groups. Primary risk factors in the pathogenesis of gall stone formation include cholesterol supersaturation in the solutes that precipitate from bile, hypernucleation (measured as "crystal appearance time') and finally hypomotility of the gall bladder which allows bile stasis and crystal formation. While the results of epidemiological studies suggest that physical activity may be inversely associated with gall stone disease, the mechanisms by which exercise may influence gall stone disease patho...Continue Reading

Citations

Sep 9, 1999·The New England Journal of Medicine·K J Vega, D E Johnston
Nov 8, 2007·Medicine and Science in Sports and Exercise·Andrea M KriskaBarbara V Howard
Jun 13, 2015·Sports Medicine·Roy J Shephard
Jul 26, 2005·Preventive Medicine·Kristi L StortiAndrea M Kriska
Jun 23, 2001·The American Journal of Gastroenterology·C Z ChuangA Lopez
Jan 12, 2008·Journal of Applied Physiology·Kenneth R WilundKijin Kim
May 26, 2018·European Journal of Clinical Investigation·Emilio Molina-MolinaPiero Portincasa

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