Abstract
Recently, glucagon-like peptide-1 (GLP-1) receptor agonists have become a cornerstone for the treatment of obese patients with type 2 diabetes (T2D), exhibiting favorable effects on the cardiovascular outcome. In T2D, impaired GLP-1 secretion/function is observed, and gut microbiota dysbiosis is related to the GLP-1 resistance. Prior research has revealed that exercise increases GLP-1 levels in healthy and obese individuals; however, the efficacy of exercise on GLP-1 levels in patients with T2D remains unclear. Exercise may improve GLP-1 resistance rather than GLP-1 secretion in patients with T2D. Exercise increases the gut microbiota diversity, which could contribute to improving the GLP-1 resistance of T2D. Furthermore, the gut microbiota may play a role in the correlation between exercise and GLP-1. The combination of exercise and GLP-1-based therapy may have a synergistic effect on the treatment of T2D. Although the underlying mechanism remains unknown, exercise potentiates the efficacy of GLP-1 receptor agonist treatment in patients with T2D.
References
Jan 23, 2009·The Journal of Endocrinology·Shin-ya UedaShigeo Fujimoto
Sep 10, 2009·The Journal of Endocrinology·Shin-ya UedaShigeo Fujimoto
Sep 16, 2009·The Journal of Physiology·Bente K Pedersen
Feb 13, 2010·The Journal of Clinical Endocrinology and Metabolism·C MartinsJ E Blundell
Aug 25, 2011·Endocrinology·Joan VendrellFrancisco J Tinahones
Dec 11, 2013·Canadian Journal of Diabetes·Saeed Reza Toghi EshghiNormand G Boulé
Jan 7, 2014·Advances in Immunology·Jian TanLaurence Macia
May 16, 2014·Medicine and Science in Sports and Exercise·Catia MartinsNeil A King
Sep 16, 2014·Frontiers in Endocrinology·Kenneth R WattersonGraeme Milligan
Nov 25, 2014·Cell·John A HawleyJuleen R Zierath
Dec 9, 2015·Journal of Physical Therapy Science·Sung Soo LeeYong Seok So
Apr 2, 2016·Journal of Applied Physiology·Emily L KullmanJohn P Kirwan
Aug 10, 2016·Journal of Diabetes and Its Complications·Jia LiuGuang Wang
Nov 5, 2016·Diabetes, Obesity & Metabolism·P MensbergT Vilsbøll
Nov 1, 2016·World Journal of Diabetes·Sanjay ChatterjeeSaurav Chatterjee
Nov 3, 2016·Current Diabetes Reviews·Hidetaka Hamasaki
May 4, 2017·Cell Metabolism·Estelle GrassetRémy Burcelin
Jul 1, 2017·Journal of Integrative Medicine·Hidetaka Hamasaki
Sep 6, 2017·The Journal of Endocrinology·Adrian Holliday, Andrew Blannin
Nov 23, 2017·Medicine and Science in Sports and Exercise·Jacob M AllenJeffrey A Woods
Jan 9, 2018·Endocrine Reviews·Abraham S MeijnikmanHilde Herrema
Mar 2, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Charlotte Bayer ChristiansenJens Juul Holst
May 3, 2018·Diabetologia·Marja A HeiskanenJarna C Hannukainen
May 8, 2018·Nature Reviews. Endocrinology·Andreas AndersenTina Vilsbøll
Citations
Dec 28, 2018·World Journal of Diabetes·Hidetaka Hamasaki
May 29, 2020·Clinical and Translational Gastroenterology·Lourdes Ortiz-AlvarezBorja Martinez-Tellez
Aug 28, 2021·Mediators of Inflammation·Lili ZhangHonggang Wang