Exercise and in vivo natural cytotoxicity against tumour cells of varying metastatic capacity

Clinical & Experimental Metastasis
L Jadeski, L Hoffman-Goetz

Abstract

Identification of modifiable risk factors which contribute to tumour metastasis is an important goal of cancer prevention research. This study was designed to evaluate the role of moderate exercise conditioning on the in vivo retention of radiolabelled H-ras-transformed fibroblasts (CIRAS 1 and CIRAS 3 cell lines) in mice with (C3H/He-bg2J/+) and without (C3H/HeJ) the beige (bg) mutation which produces impaired natural killer (NK) cell function. Mice were randomly assigned to treadmill training (20 m/min, 30 min/day, 5 times/week) or remained sedentary for 9 weeks. C3H beige mice had significantly higher retention in the lungs of CIRAS 1 tumour cells (P < 0.0001) than genotypically normal C3H/HeJ mice. There was a significant main effect of exercise conditioning (P < 0.05) with trained mice (irrespective of genotype) having lower tumour retention (44 +/- 3%) than sedentary controls (53 +/- 3%). Comparing the in vivo retention of CIRAS 1 and CIRAS 3 in the lungs of genotypically normal mice, we observed higher retention of CIRAS 1 (48 +/- 2%, compared with 18 +/- 2% for CIRAS 3; P < 0.0001). There was a significant interaction effect of exercise and tumour type (P < 0.05); trained mice had a lower retention for CIRAS 1 than sede...Continue Reading

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Citations

Jan 5, 2014·Brain, Behavior, and Immunity·Marco Antonio Moro-GarcíaRebeca Alonso-Arias
Dec 12, 2003·Integrative Cancer Therapies·Keith I BlockAristo Vojdani
Nov 6, 2003·Medicine and Science in Sports and Exercise·Laurie Hoffman-Goetz
Jan 16, 2020·Cancers·Sophie van Doorslaer de Ten Ryen, Louise Deldicque
Jul 14, 2000·Physiological Reviews·B K Pedersen, L Hoffman-Goetz
Mar 3, 1998·Nutrition Reviews·L Hoffman-Goetz
Jan 16, 2020·Cancer Metastasis Reviews·Cecilia Rincón-CastanedoCarmen Fiuza-Luces

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