Exercise and inflammation in pediatric Crohn's disease

International Journal of Sports Medicine
H PloegerB Timmons

Abstract

We examined inflammatory cells, cytokines and growth factors in response to acute bouts of moderate intensity continuous exercise and high intensity intermittent exercise in youth with Crohn's disease and in healthy matched-controls. 15 patients and 15 controls performed 30 min of cycling at 50% of peak mechanical power (PMP) and 6 bouts of 4×15-s of cycling at 100% PMP. Blood was collected at rest, at the mid-point, at the end of exercise and at 30 and 60 min into recovery. In patients with CD, both types of exercise increased immune cells and GH and decreased IGF-I. Moderate intensity exercise induced a greater increase in leukocytes (p<0.05), neutrophils (p<0.05), lymphocytes (p<0.001), monocytes (p<0.05), IL-6 (p<0.05), IL-17 (p<0.05) and GH (p<0.05) and a similar decrease in IGF-I, compared with high intensity exercise. TNF-α did not change significantly with either exercise. Responses in patients were similar compared with controls; however, in patients monocytes remained elevated significantly longer in response to MICE. Youth with Crohn's disease can engage in distinctly different types of exercise without a significant acute exacerbation of inflammation.

Citations

Oct 10, 2013·Inflammatory Bowel Diseases·Thanh NguyenBrian W Timmons
May 31, 2014·BioMed Research International·Jan BilskiTomasz Brzozowski
Jul 31, 2012·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Liesbet De BaetsSara Van Deun
Feb 28, 2015·Inflammatory Bowel Diseases·Patricia D JonesMillie D Long
Jun 4, 2016·Pharmacological Reports : PR·Jan BilskiTomasz Brzozowski
Dec 15, 2010·The Journal of Pediatrics·Hilde E PloegerBrian W Timmons
Oct 9, 2015·Multiple Sclerosis : Clinical and Laboratory Research·E Ann YehRobert W Motl
Jun 8, 2017·Alimentary Pharmacology & Therapeutics·R J S CostaP R Gibson
Feb 8, 2018·European Journal of Applied Physiology·Katrina TaylorChantal A Vella
Dec 1, 2018·Journal of Pediatric Gastroenterology and Nutrition·Margaux J BarnesBarbara Gower
Dec 29, 2017·Pediatric Exercise Science·Bareket FalkHan C G Kemper
Mar 7, 2021·Nutrients·Amritpal DhaliwalSheldon C Cooper
Jul 7, 2021·Alimentary Pharmacology & Therapeutics·Jordan J McGingGordon W Moran
Aug 21, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jérémy VanhelstDelphine Ley

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