Exercise and medication effects on persons with Parkinson disease across the domains of disability: a randomized clinical trial

Journal of Neurologic Physical Therapy : JNPT
Leland E DibblePaul C Lastayo

Abstract

Hypokinesia and bradykinesia as movement deficits of Parkinson disease are thought to be mediated by both basal ganglia dysfunction and a loss of muscle mass and strength commensurate with aging and decreased levels of physical activity. For these reasons, we sought to utilize resistance training as a means to increase muscle force and minimize hypokinesia and bradykinesia in persons with Parkinson disease and examine the effects of exercise and medication on Body Structure and Function (muscle force production and muscle cross-sectional area), Activity (mobility), and Participation (Health Status) outcomes. Forty-two participants were enrolled in a 12-week randomized clinical trial that compared 2 active exercise interventions: a standard care control group (Active Control) and an experimental group that underwent Resistance Exercise via Negative Eccentric Work (RENEW). Participants in both groups improved in muscle force production and mobility as a result of exercise and medication (P < 0.02). There were no significant interaction or between-group differences and no significant changes in muscle cross-sectional area or health status were observed. Effect sizes for exercise and medication combined exceeded the effect sizes of...Continue Reading

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Citations

Jul 5, 2016·Neuroscience and Biobehavioral Reviews·Tetsuya AsakawaYing Xia
Mar 7, 2017·Journal of Neurologic Physical Therapy : JNPT·Cory ChristiansenEd Melanson
Mar 24, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Susan H FoxUNKNOWN Movement Disorder Society Evidence-Based Medicine Committee
Oct 14, 2017·Nature Reviews. Neurology·Margaret K MakChloe L Chung
Dec 31, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Gretchen O ReynoldsAlice Cronin-Golomb
Aug 15, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Bastiaan R BloemGeorg Ebersbach
Mar 6, 2015·Journal of Neurologic Physical Therapy : JNPT·Jennifer L Wilhelm, Laurie A King
Jun 10, 2020·Aging Clinical and Experimental Research·Camilla MartignonMassimo Venturelli
Mar 6, 2015·Journal of Neurologic Physical Therapy : JNPT·Edelle Field-Fote
Jul 22, 2020·Neurology·Cynthia K López BotelloPatricia R Ancer Rodríguez
Jan 19, 2020·Journal of the Neurological Sciences·Daniel G MinerEmily DiSalvo
Mar 21, 2021·Seminars in Neurology·Terry D EllisLeland E Dibble
Apr 1, 2021·Disability and Rehabilitation. Assistive Technology·Natalie HellmersClaire Henchcliffe

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