Exercise as a potential treatment for drug abuse: evidence from preclinical studies.

Frontiers in Psychiatry
Mark A Smith, Wendy J Lynch

Abstract

Epidemiological studies reveal that individuals who engage in regular aerobic exercise are less likely to use and abuse illicit drugs. Until recently, very few studies had examined the causal influences that mediate this relationship, and it was not clear whether exercise was effective at reducing substance use and abuse. In the past few years, several preclinical studies have revealed that exercise reduces drug self-administration in laboratory animals. These studies have revealed that exercise produces protective effects in procedures designed to model different transitional phases that occur during the development of, and recover from, a substance use disorder (e.g., acquisition, maintenance, escalation, and relapse/reinstatement of drug use). Moreover, recent studies have revealed several behavioral and neurobiological consequences of exercise that may be responsible for its protective effects in these assays. Collectively, these studies have provided convincing evidence to support the development of exercise-based interventions to reduce compulsive patterns of drug intake in clinical and at-risk populations.

Citations

Mar 7, 2014·Psychopharmacology·Natalie E ZlebnikMarilyn E Carroll
Aug 19, 2014·Life Sciences·Ryan T LacyMark A Smith
Nov 15, 2014·The American Journal of Drug and Alcohol Abuse·Sarah E Linke, Michael Ussher
Mar 5, 2016·Health and Quality of Life Outcomes·Ashley E MullerThomas Clausen
Nov 26, 2015·Journal of Psychoactive Drugs·Jorge Giménez-MeseguerMaría de los Remedios Fernández-Valenciano
Apr 16, 2013·Drug and Alcohol Dependence·Janet Audrain-McGovernJoseph Sass
Feb 3, 2015·Journal of Substance Abuse Treatment·Esther S GiesenWilhelm Bloch
Oct 21, 2014·PloS One·Dongshi WangChenglin Zhou
Jun 28, 2016·Addiction Biology·Marilyn E Carroll, Wendy J Lynch
Oct 25, 2016·Journal of Neuroscience Methods·Justin C Strickland, Mark A Smith
Dec 28, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert W GouldMichael A Nader
Aug 15, 2018·International Journal of Adolescent Medicine and Health·Andrea LukácsEmőke Kiss-Tóth
Mar 1, 2017·Frontiers in Psychiatry·Adonis SferaMichael Cummings
Sep 12, 2019·Frontiers in Psychiatry·Kell Grandjean CostaEduardo Bodnariuc Fontes
Nov 7, 2020·International Journal of Environmental Research and Public Health·Jianing LiuChenglin Zhou
Apr 1, 2021·Cognitive Neurodynamics·Yingzhi LuChengling Zhou

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BETA
antisense oligonucleotides

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