Exercise differentially regulates renalase expression in skeletal muscle and kidney

The Tohoku Journal of Experimental Medicine
Bozena Czarkowska-PaczekLeszek Paczek

Abstract

Renalase is a newly discovered amine oxidase and may lower blood pressure by metabolizing catecholamines. We have hypothesized that exercise and training may regulate renalase expression to control blood pressure. In this study, we investigated changes in renalase expression after exercise and training in white and red portion of the gastrocnemius muscle, kidney, and serum in rats. Rats were either untrained or subjected to six weeks of endurance training, which predominantly recruits red fibers. Rats from each group were sacrificed before (n = 10), immediately after (n = 10), or three hours (n = 10) following exercise. Renalase mRNA and protein levels were measured by RT-PCR and ELISA, respectively. There were no significant changes in renalase expression after prolonged training or acute exercise in the serum or red muscle of rats. However, in white muscle, renalase mRNA and protein levels decreased after acute exercise in untrained rats, whereas, in trained rats, its protein level remained unchanged, despite a decrease in mRNA. Thus, exercise influenced renalase expression only in white muscle fibers that are not predominantly recruited during exercise. The reduction of renalase protein in white muscle suggests that renalase...Continue Reading

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Citations

Apr 23, 2015·Biochimica Et Biophysica Acta·Graham R Moran
Jun 7, 2015·Archives of Biochemistry and Biophysics·Brett A BeaupreGraham R Moran
Dec 3, 2014·Advances in Medical Sciences·Jolanta MalyszkoSlawomir Dobrzycki
Feb 14, 2020·FEBS Open Bio·Katsuyuki TokinoyaKazuhiro Takekoshi

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