Exercise does not influence myostatin and follistatin messenger RNA expression in young women.

Journal of Strength and Conditioning Research
Nicole E JenskyE Todd Schroeder

Abstract

We evaluated changes in myostatin, follistatin, and MyoD messenger RNA (mRNA) gene expression using eccentric exercise (EE) and concentric exercise (CE) as probes to better understand the mechanisms of muscle hypertrophy in young women. Twelve women performed single-leg maximal eccentric (n = 6, 25 +/- 1 years, 59 +/- 7 kg) or concentric (n = 6, 24 +/- 1 years, 65 +/- 7 kg) isokinetic knee extension exercise for 7 sessions. Muscle biopsies were taken from the vastus lateralis at baseline, 8 hours after the first exercise session, and 8 hours after the seventh exercise session. In the EE group, there were no changes in myostatin and follistatin (p > or = 0.17); however, MyoD expression increased after 1 exercise bout (p = 0.02). In the CE group, there were no changes in myostatin, follistatin, or MyoD mRNA gene expression (p > or = 0.07). Differences between the EE and CE groups were not significant (p > or = 0.05). These data suggest that a single bout or multiple bouts of maximal EE or CE may not significantly alter myostatin or follistatin mRNA gene expression in young women. However, MyoD mRNA expression seems to increase only after EE.

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Citations

Sep 18, 2010·Journal of Strength and Conditioning Research·Brad J Schoenfeld
Mar 8, 2012·Journal of Strength and Conditioning Research·Christina M Dieli-ConwrightE Todd Schroeder
Sep 5, 2015·Journal of Strength and Conditioning Research·Christina M Dieli-ConwrightE Todd Schroeder
Sep 14, 2016·Metabolism: Clinical and Experimental·Athanasios D AnastasilakisChristos S Mantzoros
Aug 8, 2018·The Journal of Clinical Endocrinology and Metabolism·Nikolaos PerakakisChristos S Mantzoros
Jun 27, 2019·American Journal of Physiology. Endocrinology and Metabolism·Hui-Ying LukJakob L Vingren

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