Exercise during therapeutic beta-blockade: a two-year study in hypertensive patients

Clinical Pharmacology and Therapeutics
M Frisk-Holmberg, G Ström

Abstract

The use of beta-adrenoceptor blocking drugs has been thought to impair physical performance. To test this statement, 12 patients with mild to moderate hypertension performed a submaximal exercise test during treatment with placebo and after 3 and 24 months of monotherapy with betaxolol, 20 to 40 mg daily. The resting heart rate and systolic and diastolic blood pressures were reduced after 3 months of treatment and the reduction was maintained 24 hours after the last dose at the 2-year visit. A 12% to 14% reduction of exercise-induced tachycardia was found, but blood pressure during exercise was reduced only in the patients with mild hypertension. However, in no patient did the working capacity decrease.

Citations

May 1, 1988·Indian Journal of Pediatrics·L P Roy
Jan 1, 1990·European Journal of Clinical Pharmacology·S FrankM Kohnle
Dec 1, 1987·Journal of Clinical Pharmacy and Therapeutics·J V Okopski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.