Exercise heart rates in patients with hypertrophic cardiomyopathy

The American Journal of Cardiology
Hong-Chang LuoM Roselle Abraham

Abstract

The exercise heart rate (HR) profile and its relation to cardiac function and arrhythmias were investigated in patients with hypertrophic cardiomyopathy (HC). Chronotropic response (CR) and heart rate recovery (HRR) were computed during and after treadmill exercise testing in 273 patients with HC and 95 age-matched healthy controls. Patients with HC had higher prevalence of chronotropic incompetence and lower HRR1-5min compared with controls. Exercise capacity, diastolic function (assessed by E/e') and left atrial volume index were associated with HRR1min and CR in HC. Septal myectomy was associated with reduction in chronotropic incompetence but did not affect HRR1min. In conclusion, impaired CR and HRR1min are associated with advanced disease and do not appear to be independent clinical markers indicating high-risk status in HC. Improving CR by titrating doses of negative chronotropic agents, myectomy, and atrial pacing may be useful to increase exercise capacity in patients with HC.

References

Apr 1, 1989·Circulation·J E BrushD S Goldstein
Jul 1, 1993·Journal of the American College of Cardiology·C K MorrisA Hideg
Nov 11, 1998·Journal of the American College of Cardiology·M S LauerT H Marwick
Feb 18, 1999·JAMA : the Journal of the American Medical Association·M S LauerT H Marwick
Oct 28, 1999·The New England Journal of Medicine·C R ColeM S Lauer
Sep 6, 2003·Journal of the American College of Cardiology·Abdou ElhendyPatricia A Pellikka
Sep 17, 2010·European Heart Journal·Pawel Petkow DimitrowAndrzej Wysokinski
Jan 5, 2011·Cardiovascular Research·Stefan HerrmannAndreas Ludwig
Jul 26, 2011·The Journal of Clinical Investigation·Paari Dominic SwaminathanMark E Anderson
Dec 27, 2011·Journal of Cardiac Failure·S Michael GharacholouPatricia A Pellikka

❮ Previous
Next ❯

Citations

Dec 24, 2015·European Journal of Heart Failure·Athanasia KalyvaPanos E Vardas
Mar 17, 2016·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Nasir HussainWilliam L Duvall
Apr 5, 2017·Annals of the American Thoracic Society·Damiano Magrì, Caterina Santolamazza
Nov 21, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Dai-Yin LuM Roselle Abraham
Apr 4, 2021·Journal of Clinical Medicine·Quirino Ciampi The Stress Echo Study Group On Behalf Of The Italian Society Of Echocardiography And Cardiovascular Imaging Siecvi
Jun 3, 2021·Journal of Clinical Medicine·Adrián Bayonas-RuizBárbara Bonacasa
Jul 22, 2021·Heart Failure Reviews·Thomas GossiosGeorgios K Efthimiadis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.