PMID: 11572476Sep 27, 2001

Exercise in sickle cell anemia: effect on inflammatory and vasoactive mediators

Endothelium : Journal of Endothelial Cell Research
P BarbeauB Gutin

Abstract

The aim of this study was to determine the response of inflammatory and vasoactive mediators to 3 consecutive days of exercise in African-American women with and without sickle cell anemia (SCA). Circulating inflammatory mediators [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha)] were measured before, and vasoactive mediators [endothelin-1 (ET-1), nitric oxide metabolites (NOx)] before and after each exercise bout in ten subjects with SCA and ten controls. Exercise did not affect ET-1, IL-6 or CRP concentrations (p >.05). TNFalpha was higher in SCA than controls (p < or = .0005) at all times; however, the response pattern was similar for the groups: no change from day 1 to day 2, but a decrease from day 2 to day 3 (p < or = .05). NOx increased significantly after exercise (p < or = .0001) but returned to baseline by 24 h afterward. On the 3rd day, NOx increased after exercise in SCA but not in the controls (p < or = .05). In conclusion, exercise did not cause a harmful inflammatory response in these individuals with SCA. However, NOx increased after exercise on all 3 days in SCA but appeared attenuated after 2 days in controls.

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Citations

Dec 17, 2015·Sports Medicine·Erica N ChiricoVincent Pialoux
Apr 28, 2019·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Suzanne AmeringerEdmund O Acevedo
Apr 26, 2007·Biological Research for Nursing·Chris WinkelmanAlan D Levine
Oct 3, 2006·British Journal of Haematology·Patrick B WalterPaul Harmatz
Dec 25, 2015·British Journal of Sports Medicine·Cyril MartinPhilippe Connes

Related Concepts

Anemia, Sickle Cell
C-reactive protein
Enzyme-Linked Immunosorbent Assay
Fluorescence Polarization
Pulse Rate
Hematocrit Procedure
Eryhem
Immunoassay Method
Nitric Oxide
Tumor Necrosis Factor-alpha

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