PMID: 11572476Sep 27, 2001

Exercise in sickle cell anemia: effect on inflammatory and vasoactive mediators

Endothelium : Journal of Endothelial Cell Research
P BarbeauB Gutin


The aim of this study was to determine the response of inflammatory and vasoactive mediators to 3 consecutive days of exercise in African-American women with and without sickle cell anemia (SCA). Circulating inflammatory mediators [C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha)] were measured before, and vasoactive mediators [endothelin-1 (ET-1), nitric oxide metabolites (NOx)] before and after each exercise bout in ten subjects with SCA and ten controls. Exercise did not affect ET-1, IL-6 or CRP concentrations (p >.05). TNFalpha was higher in SCA than controls (p < or = .0005) at all times; however, the response pattern was similar for the groups: no change from day 1 to day 2, but a decrease from day 2 to day 3 (p < or = .05). NOx increased significantly after exercise (p < or = .0001) but returned to baseline by 24 h afterward. On the 3rd day, NOx increased after exercise in SCA but not in the controls (p < or = .05). In conclusion, exercise did not cause a harmful inflammatory response in these individuals with SCA. However, NOx increased after exercise on all 3 days in SCA but appeared attenuated after 2 days in controls.


Nov 1, 1991·Clinical Science·L M WeightP Jacobs
Feb 1, 1991·The American Review of Respiratory Disease·P PianosiA L Coates
Jan 1, 1988·Postgraduate Medicine·P Painter, G Blackburn
Feb 1, 1983·The American Journal of Cardiology·W CovitzR H DuRant
Nov 10, 1984·British Medical Journal·A F StrachanF C de Beer
Jan 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·J L TaylorW J O'Brien
Jun 1, 1993·Journal of Internal Medicine·C C HedoL S Salimonu
Oct 1, 1994·International Journal of Sports Medicine·H NorthoffA Berg
May 1, 1994·International Journal of Sports Medicine·A RivierJ Bousquet
Dec 1, 1995·British Journal of Haematology·D C ReesJ B Porter
Dec 1, 1996·Journal of Cardiac Failure·M YokoyamaY Kawahara
Dec 1, 1996·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·B L LopezX Ma
Mar 15, 1997·The Journal of Physiology·H BruunsgaardB K Pedersen
Mar 1, 1997·Medicine and Science in Sports and Exercise·C WeinstockH Northoff
Sep 11, 1997·The New England Journal of Medicine·H F Bunn
Aug 4, 1998·European Journal of Haematology·K L BourantasA Mavridis
Dec 5, 1998·Canadian Journal of Physiology and Pharmacology·B K PedersenH Bruunsgaard
Mar 19, 1999·Clinical and Experimental Pharmacology & Physiology·D M Pollock
Apr 8, 1999·Journal of the American College of Cardiology·P ClarksonJ E Deanfield


Dec 17, 2015·Sports Medicine·Erica N ChiricoVincent Pialoux
Apr 28, 2019·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Suzanne AmeringerEdmund O Acevedo
Apr 26, 2007·Biological Research for Nursing·Chris WinkelmanAlan D Levine
Oct 3, 2006·British Journal of Haematology·Patrick B WalterPaul Harmatz
Dec 25, 2015·British Journal of Sports Medicine·Cyril MartinPhilippe Connes

Related Concepts

Anemia, Sickle Cell
C-reactive protein
Enzyme-Linked Immunosorbent Assay
Fluorescence Polarization
Pulse Rate
Hematocrit Procedure
Immunoassay Method
Nitric Oxide
Tumor Necrosis Factor-alpha

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
E V GranowitzC A Dinarello
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M H BemelmansW A Buurman
© 2021 Meta ULC. All rights reserved