Exercise Increases Insulin Sensitivity and Skeletal Muscle AMPK Expression in Systemic Lupus Erythematosus: A Randomized Controlled Trial

Frontiers in Immunology
Fabiana B BenattiBruno Gualano

Abstract

Systemic lupus erythematosus (SLE) patients may show increased insulin resistance (IR) when compared with their healthy peers. Exercise training has been shown to improve insulin sensitivity in other insulin-resistant populations, but it has never been tested in SLE. Therefore, the aim of the present study was to assess the efficacy of a moderate-intensity exercise training program on insulin sensitivity and potential underlying mechanisms in SLE patients with mild/inactive disease. A 12-week, randomized controlled trial was conducted. Nineteen SLE patients were randomly assigned into two groups: trained (SLE-TR, n = 9) and non-trained (SLE-NT, n = 10). Before and after 12 weeks of the exercise training program, patients underwent a meal test (MT), from which surrogates of insulin sensitivity and beta-cell function were determined. Muscle biopsies were performed after the MT for the assessment of total and membrane GLUT4 and proteins related to insulin signaling [Akt and AMP-activated protein kinase (AMPK)]. SLE-TR showed, when compared with SLE-NT, significant decreases in fasting insulin [-39 vs. +14%, p = 0.009, effect size (ES) = -1.0] and in the insulin response to MT (-23 vs. +21%, p = 0.007, ES = -1.1), homeostasis model...Continue Reading

Associated Clinical Trials

References

Mar 1, 1988·The American Journal of Physiology·K J MikinesH Galbo
Jan 1, 1987·The Journal of Clinical Endocrinology and Metabolism·G M ReavenJ B Jaspan
Sep 10, 1999·BMJ : British Medical Journal·S Hollis, F Campbell
Sep 11, 2001·The Journal of Clinical Endocrinology and Metabolism·S E Kahn
Mar 2, 2002·Journal of Diabetes and Its Complications·Alain D Baron
Sep 21, 2002·BMJ : British Medical Journal·Dean FergussonPaul Hébert
Nov 26, 2003·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·R Ramsey-GoldmanR W Chang
Mar 5, 2004·American Journal of Public Health·Cesar G VictoraJennifer Bryce
Apr 20, 2005·Annals of Internal Medicine·Trevor J OrchardUNKNOWN Diabetes Prevention Program Research Group
Dec 6, 2005·Diabetes Research and Clinical Practice·Andrea TuraGiovanni Pacini
Sep 12, 2007·Diabetologia·E FerranniniUNKNOWN Relationship between Insulin Sensitivity and Cardiovascular Disease Risk (RISC) Project Investigators
Oct 25, 2007·American Journal of Physiology. Endocrinology and Metabolism·Ranganath MuniyappaMichael J Quon
Mar 20, 2008·Current Opinion in Rheumatology·Allyson K McDonoughKenneth G Saag
Oct 1, 2010·Medicine and Science in Sports and Exercise·Bruno GualanoAntonio Herbert Lancha
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·D Grahame HardieSimon A Hawley
Mar 28, 2013·Arthritis Research & Therapy·Danilo M L PradoHamilton Roschel
Jul 17, 2013·Molecular and Cellular Biology·Partha ChakrabartiKonstantin V Kandror
Aug 24, 2013·Rheumatology·Edgard Torres dos Reis-NetoEmilia Inoue Sato
Jun 29, 2014·Rheumatology International·Fabiana Braga BenattiAna Lúcia de Sá Pinto
Jul 20, 2014·Journal of Applied Physiology·Luiz A PerandiniBruno Gualano
Nov 4, 2016·Nature Reviews. Endocrinology·Lykke SylowThomas E Jensen
Sep 8, 2017·BMJ Open Sport & Exercise Medicine·Stephen R Bird, John A Hawley

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Citations

Nov 7, 2019·Rheumatology·Anselm Mak
May 24, 2019·Frontiers in Physiology·Emmanuelle RochettePascale Duché

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Methods Mentioned

BETA
biopsies
X-ray
biopsy

Clinical Trials Mentioned

NCT01515163

Software Mentioned

SAS
Scion Image
Virtual Nutri ®
SLE
Power

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