Exercise Increases MAIT Cell Cytokine Expression but not Activation or Homing Markers

Medicine and Science in Sports and Exercise
Erik D HansonSamy Sakkal

Abstract

Mucosal associated invariant T (MAIT) have properties of both the innate and adaptive immune systems but are an understudied population within exercise immunology. These lymphocytes aggregate at the mucous membranes, but it is unknown if submaximal exercise alters their circulating numbers or function. To determine the MAIT cell response to submaximal exercise on activation and homing marker expression and stimulated cytokine production. Twenty healthy, young, recreationally active males cycled for 40 min at 86% of VT following an overnight fast. Peripheral blood mononuclear cells were isolated and labelled to identify specific MAIT cell populations using flow cytometry. Cytokine production following stimulation was also determined. MAIT cells were 2.9% of T-cells and increased to 3.9% after exercise and with recovery whereas cell numbers significantly increased by 91.5% following exercise before returning to resting levels. Chemokine and activation marker absolute cell number significantly increased while expression levels remained constant but the high levels of CCR5 may help direct MAIT cells to sites of inflammation. Following stimulation, TNFα expression significantly increased after exercise before returning to baseline w...Continue Reading

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Citations

Jul 17, 2019·Nature Reviews. Immunology·Amine ToubalAgnès Lehuen

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