Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes

Diabetes, Obesity & Metabolism
S E HusseyM Hargreaves

Abstract

The aim of the study was to determine the effect of a single bout of exercise on GLUT4 gene expression in muscle of patients with type 2 diabetes (T2D) and control subjects, matched for age and body mass index. Nine patients with T2D and nine control subjects performed 60 min of cycling exercise at ~55% peak power (W(max) ). Skeletal muscle biopsies were obtained at baseline, immediately post and 3-h post exercise. GLUT4 mRNA expression increased (p < 0.05) to a similar extent immediately post exercise in control (~60%) and T2D (~66%) subjects, and remained elevated (p < 0.05) 3-h post exercise with no differences between groups. Similarly, p-AMP-activated protein kinase, p38 mitogen-activated kinase and proliferator-activated receptor gamma co-activator-alpha mRNA expression were increased (p < 0.05) post exercise, and were not different between the groups. In conclusion, a single bout of exercise increased skeletal muscle GLUT4 mRNA expression in patients with T2D to a similar extent as in control subjects.

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Citations

May 15, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Philip M GallagherMichael J Wacker
Feb 14, 2014·Cell Stress & Chaperones·Philip L HooperLaszlo Vigh
Apr 25, 2014·British Journal of Sports Medicine·Alison R Harmer, Mark R Elkins
Aug 21, 2013·The International Journal of Neuropsychopharmacology·H N BoydaA M Barr
Oct 1, 2015·Archives of Endocrinology and Metabolism·Rogério de Oliveira-BatistaPatricia Monteiro Seraphim
Apr 6, 2017·Microarrays·Mary Shannon ByersXiaofei Wang
Dec 23, 2017·Medicine and Science in Sports and Exercise·Kendra D StickaKriya L Dunlap
May 29, 2019·The Journal of Clinical Endocrinology and Metabolism·Rugivan SabaratnamKurt Højlund
Dec 1, 2014·Advances in Physiology Education·Kristin I Stanford, Laurie J Goodyear
Jan 2, 2014·Molecular Biology Reports·Liqi ZhuQian Yang
May 17, 2017·Cold Spring Harbor Perspectives in Medicine·Kristin I Stanford, Laurie J Goodyear
Jun 23, 2020·Exercise and Sport Sciences Reviews·Marcelo Flores-OpazoMark Hargreaves
Mar 28, 2020·Oxidative Medicine and Cellular Longevity·Habib YaribeygiAmirhossein Sahebkar

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