Exercise-induced 3'-sialyllactose in breast milk is a critical mediator to improve metabolic health and cardiac function in mouse offspring.

Nature Metabolism
Johan E HarrisKristin I Stanford

Abstract

Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9. Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified. In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL. In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice. There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood. Importantly, supplementation of...Continue Reading

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Citations

Jul 18, 2020·Nature Reviews. Cardiology·Shimona Starling
Jul 23, 2020·Nature Metabolism·Jose B N Moreira, Ulrik Wisløff
Jul 15, 2020·Nature Reviews. Endocrinology·Shimona Starling
Sep 16, 2020·Nature Metabolism·Joji KusuyamaLaurie J Goodyear
Oct 22, 2020·Cellular and Molecular Life Sciences : CMLS·Caitlyn E BowmanMichael J Wolfgang
Nov 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Danielle WolfsElvira Isganaitis
Mar 2, 2021·Frontiers in Immunology·Laura E CarrLaxmi Yeruva
Feb 14, 2021·European Journal of Clinical Investigation·Jorge BelezaJosé Magalhães
Apr 29, 2021·Critical Reviews in Food Science and Nutrition·Jielong GuoJicheng Zhan
Jun 11, 2021·Frontiers in Immunology·Anaïs RousseauxMarie Bodinier
Aug 4, 2021·International Journal of Sports Medicine·Polina M KrassovskaiaNicholas T Broskey

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Methods Mentioned

BETA
PCR
ELISA

Clinical Trials Mentioned

NCT01131117

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