Abstract
Poor maternal environments, such as under- or overnutrition, can increase the risk for the development of obesity, type 2 diabetes and cardiovascular disease in offspring1-9. Recent studies in animal models have shown that maternal exercise before and during pregnancy abolishes the age-related development of impaired glucose metabolism10-15, decreased cardiovascular function16 and increased adiposity11,15; however, the underlying mechanisms for maternal exercise to improve offspring's health have not been identified. In the present study, we identify an exercise-induced increase in the oligosaccharide 3'-sialyllactose (3'-SL) in milk in humans and mice, and show that the beneficial effects of maternal exercise on mouse offspring's metabolic health and cardiac function are mediated by 3'-SL. In global 3'-SL knockout mice (3'-SL-/-), maternal exercise training failed to improve offspring metabolic health or cardiac function in mice. There was no beneficial effect of maternal exercise on wild-type offspring who consumed milk from exercise-trained 3'-SL-/- dams, whereas supplementing 3'-SL during lactation to wild-type mice improved metabolic health and cardiac function in offspring during adulthood. Importantly, supplementation of...Continue Reading
References
Aug 12, 1976·The New England Journal of Medicine·G P RavelliM W Susser
Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Jul 1, 1981·Endocrinology·R M AkersH A Tucker
Mar 1, 1993·Diabetologia·K PhippsP M Clark
Mar 29, 2000·Theriogenology·D J Barker
Oct 11, 2003·Endocrinology·Diana C AlbaradoAndrew A Butler
Feb 12, 2009·Diabetes·Elvira IsganaitisMary-Elizabeth Patti
Nov 26, 2010·The Journal of Experimental Medicine·Andrea FuhrerThierry Hennet
Jan 21, 2011·Stem Cells and Development·Melissa WooMary Elizabeth Patti
Apr 20, 2012·Glycobiology·Lars Bode
Aug 31, 2012·American Journal of Physiology. Endocrinology and Metabolism·Lindsay G CarterKevin J Pearson
Dec 19, 2012·Medicine and Science in Sports and Exercise·Lindsay G CarterKevin J Pearson
Apr 24, 2013·Diabetes·Sarah J LessardLaurie J Goodyear
Sep 21, 2013·Journal of Pediatric Gastroenterology and Nutrition·Carolin F MantheyLars Bode
Nov 5, 2013·Diabetes·Elvira IsganaitisMary-Elizabeth Patti
Jan 17, 2014·Diabetes·Rhianna C LakerZhen Yan
Apr 18, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ding AnLaurie J Goodyear
Sep 11, 2014·Diabetes·Kristin I StanfordLaurie J Goodyear
Jan 18, 2015·Journal of Molecular and Cellular Cardiology·Steve R RoofMark T Ziolo
Dec 31, 2016·Neuroscience and Biobehavioral Reviews·Richard McCarty
Jun 3, 2017·Diabetes·Kristin I StanfordLaurie J Goodyear
Aug 7, 2017·Journal of Dairy Science·Taksawan ThongaramMichael J Miller
Feb 7, 2018·Trends in Endocrinology and Metabolism : TEM·Johan E HarrisKristin I Stanford
Aug 18, 2018·European Journal of Epidemiology·Dong Hoon LeeEdward L Giovannucci
Oct 9, 2018·Molecular Metabolism·Jessica H BeesonSusan E Ozanne
Oct 23, 2018·Diabetes·Kristin I StanfordLaurie J Goodyear
Nov 18, 2018·Current Developments in Nutrition·Marcia H MonacoSharon M Donovan
Citations
Jul 18, 2020·Nature Reviews. Cardiology·Shimona Starling
Jul 23, 2020·Nature Metabolism·Jose B N Moreira, Ulrik Wisløff
Jul 15, 2020·Nature Reviews. Endocrinology·Shimona Starling
Sep 16, 2020·Nature Metabolism·Joji KusuyamaLaurie J Goodyear
Oct 22, 2020·Cellular and Molecular Life Sciences : CMLS·Caitlyn E BowmanMichael J Wolfgang
Nov 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Danielle WolfsElvira Isganaitis
Jan 27, 2021·Nutrients·Junilla K Larsen, Lars Bode
Mar 2, 2021·Frontiers in Immunology·Laura E CarrLaxmi Yeruva
Mar 3, 2021·Cell Metabolism·Xiaoning LiuXuebo Liu
Feb 14, 2021·European Journal of Clinical Investigation·Jorge BelezaJosé Magalhães
Apr 29, 2021·Critical Reviews in Food Science and Nutrition·Jielong GuoJicheng Zhan
Jun 11, 2021·Frontiers in Immunology·Anaïs RousseauxMarie Bodinier
Dec 15, 2020·Neuroscience Research·Shiro Tochitani
Jun 19, 2021·Molecules and Cells·Sun-Kyung Lee
Aug 4, 2021·International Journal of Sports Medicine·Polina M KrassovskaiaNicholas T Broskey